全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ernst Wagner , Wolfgang Schaper ...
来源:[J].BMC Developmental Biology(IF 2.728), 2011, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)The zinc finger transcription factor Egr-1 (Early growth response 1) is central to several growth factors and represents an important activator of target genes not only involved in physiological processes like embryogenesis and neonatal development, b...
作者:Ernst Wagner , Harald Ehrhardt ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (12)DOAJ
摘要:Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines. As qualified exemplary model, patients' acute lymphoblastic leukemia cells ...
作者:... Manfred Ogris , Ernst Wagner , Alexander Levitzki
来源:[J].PLoS Medicine(IF 16.269), 2006, Vol.3 (1)DOAJ
摘要:BACKGROUND: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12-14 mo from the time of diagnosis. We describe a novel strategy to selectively induce the death of glioblastoma cells and other cancer cell...
作者:... Ulrich Lächelt , Taavi Lehto , Ernst Wagner
来源:[J].Biomaterials(IF 7.604), 2016, Vol.77, pp.98-110Elsevier
摘要:Abstract(#br)Synthetic small interfering RNA (siRNA) is a class of therapeutic entities that allow for specific silencing of target genes via RNA interference (RNAi) and comprise an enormous clinical potential for a variety of diseases, including cancer. However, efficient tissue...
作者:... Jan Gorges , Uli Kazmaier , Ernst Wagner
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2019, Vol.569Elsevier
摘要:Abstract(#br)Small interfering RNA (siRNA) represents a new class of therapeutic agents. Its successful intracellular delivery is a major challenge. Lipo-oligomeric carriers can complex siRNA into lipopolyplexes and thus mediate its cellular uptake. In this study, siRNA against t...

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