全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ernest Fraenkel , Rudolf Jaenisch
来源:[J].PLoS Genetics(IF 8.517), 2017, Vol.9 (2)DOAJ
摘要:SOX2 is a master regulator of both pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs); however, we currently lack a detailed understanding of how SOX2 controls these distinct stem cell populations. Here we show by genome-wide analysis that, whi...
作者:... Francesco Bertoni , Ernest Fraenkel , Ivo Kwee
来源:[J].PLoS Computational Biology(IF 5.215), 2017, Vol.13 (7)DOAJ
摘要:With the recent technological developments a vast amount of high-throughput data has been profiled to understand the mechanism of complex diseases. The current bioinformatics challenge is to interpret the data and underlying biology, where efficient algorithms for analyzing heter...
作者:... William Gordon , Douglas A Lauffenburger , Ernest Fraenkel
来源:[J].PLoS Computational Biology(IF 4.867), 2017, Vol.9 (2)DOAJ
摘要:Cellular signal transduction generally involves cascades of post-translational protein modifications that rapidly catalyze changes in protein-DNA interactions and gene expression. High-throughput measurements are improving our ability to study each of these stages individual...
作者:Amanda Kedaigle , Ernest Fraenkel
来源:[J].Current Opinion in Pharmacology(IF 5.443), 2018, Vol.42, pp.95-101Elsevier
摘要:Omics technologies have made it easier and cheaper to evaluate thousands of biological molecules at once. These advances have led to novel therapies approved for use in the clinic, elucidated the mechanisms behind disease-associated mutations, led to increased accuracy in disease...
作者:... Michael T. Hemann , Ernest Fraenkel , Douglas A. Lauffenburger
来源:[J].Seminars in Cancer Biology(IF 7.436), 2013, Vol.23 (4), pp.213-218Elsevier
摘要:Abstract(#br)RNA-interference (RNAi) studies hold great promise for functional investigation of the significance of genetic variations and mutations, as well as potential synthetic lethalities, for understanding and treatment of cancer, yet technical and conceptual issues cu...

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