全部文献期刊会议图书|学者科研项目
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作者:... Nicholas D. Allen , Ernest Fraenkel , Leslie M. Thompson
来源:[J].Stem Cell Reports, 2020, Vol.14 (3), pp.406-419
摘要:Summary(#br)Aberrant neuronal development and the persistence of mitotic cellular populations have been implicated in a multitude of neurological disorders, including Huntington's disease (HD). However, the mechanism underlying this potential pathology remains unclear. We used a ...
作者:Ernest Fraenkel , Karen E. Duff
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (Pt 2), pp.507-537Springer
摘要:Abstract(#br)The ε4 allele of apolipoprotein E ( APOE ) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason for the association between APOE4 and AD remains unclear. While much of the research has focused on the ability of the apo...
作者:... Brook T. Wassie , Pamela Milani , Ernest Fraenkel
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (1), pp.424-43.e7Springer
摘要:Abstract(#br)High-throughput screening and gene signature analyses frequently identify lead therapeutic compounds with unknown modes of action (MoAs), and the resulting uncertainties can lead to the failure of clinical trials. We developed an approach for uncovering MoAs thr...
作者:Ernest Fraenkel , Rudolf Jaenisch
来源:[J].PLoS Genetics(IF 8.517), 2017, Vol.9 (2)DOAJ
摘要:SOX2 is a master regulator of both pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs); however, we currently lack a detailed understanding of how SOX2 controls these distinct stem cell populations. Here we show by genome-wide analysis that, whi...
作者:... Francesco Bertoni , Ernest Fraenkel , Ivo Kwee
来源:[J].PLoS Computational Biology(IF 5.215), 2017, Vol.13 (7)DOAJ
摘要:With the recent technological developments a vast amount of high-throughput data has been profiled to understand the mechanism of complex diseases. The current bioinformatics challenge is to interpret the data and underlying biology, where efficient algorithms for analyzing heter...
作者:... William Gordon , Douglas A Lauffenburger , Ernest Fraenkel
来源:[J].PLoS Computational Biology(IF 4.867), 2017, Vol.9 (2)DOAJ
摘要:Cellular signal transduction generally involves cascades of post-translational protein modifications that rapidly catalyze changes in protein-DNA interactions and gene expression. High-throughput measurements are improving our ability to study each of these stages individual...
作者:Amanda Kedaigle , Ernest Fraenkel
来源:[J].Current Opinion in Pharmacology(IF 5.443), 2018, Vol.42, pp.95-101Elsevier
摘要:Omics technologies have made it easier and cheaper to evaluate thousands of biological molecules at once. These advances have led to novel therapies approved for use in the clinic, elucidated the mechanisms behind disease-associated mutations, led to increased accuracy in disease...
作者:Ernest Fraenkel , David A. Weitz ...
来源:[J].Nature Communications(IF 10.015), 2018, Vol.9 (1), pp.1-14DOAJ
摘要:Alexander disease is a rare neurodegeneration caused by mutations in a glial gene GFAP. Here, Wang and colleagues show in animal models of Alexander disease that GFAP mutant brain and cells have greater tissue and cellular stiffness and greater activation of mechanosensitive sign...

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