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作者:... Sumanta K. Pal , Eric C. Bolton , Jeremy O. Jones
来源:[J].The Prostate(IF 3.843), 2018, Vol.78 (7), pp.521-531
摘要:Background(#br)Androgens and the androgen receptor (AR) are necessary for the development, function, and homeostatic growth regulation of the prostate gland. However, once prostate cells are transformed, the AR is necessary for the proliferation and survival of the malignant...
作者:Congcong Chen , Jason A. Dienhart , Eric C. Bolton
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (5)
摘要:Androgen receptor (AR) signaling is crucial to the development and homeostasis of the prostate gland, and its dysregulation mediates common prostate pathologies. The mechanisms whereby AR regulates growth suppression and differentiation of luminal epithelial cells in the pro...
作者:Young-Chae Kim , Congcong Chen , Eric C. Bolton
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (9)
摘要:The androgen receptor (AR) mediates the developmental, physiologic, and pathologic effects of androgens including 5α-dihydrotestosterone (DHT). However, the mechanisms whereby AR regulates growth suppression and differentiation of luminal epithelial cells in the prostate gla...
作者:Eric C. Bolton , Yong Huang ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2009, Vol.106 (17), pp.7233-7238
摘要:Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available anti-androgens target only ligand binding, either by reduction of available hormone or by competitive antagonism....

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