全部文献期刊会议图书|学者科研项目
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作者:Elizabeth M. Smith , Jared Hennen ...
来源:[J].Analytical Biochemistry(IF 2.582), 2015, Vol.480, pp.11-20
摘要:Abstract(#br)This study introduces a technique that characterizes the spatial distribution of peripheral membrane proteins that associate reversibly with the plasma membrane. An axial scan through the cell generates a z-scan intensity profile of a fluorescently labeled peripheral...
作者:Elizabeth M. Smith , Jared Hennen ...
来源:[J].Biophysical Journal(IF 3.668), 2015, Vol.108 (11), pp.2648-2657
摘要:Abstract(#br)This study presents a fluorescence-based assay that allows for direct measurement of protein binding to the plasma membrane inside living cells. An axial scan through the cell generates a fluorescence intensity profile that is analyzed to determine the membrane-...
作者:Elizabeth M. Smith , Patrick J. Macdonald ...
来源:[J].Biophysical Journal(IF 3.668), 2014, Vol.107 (1), pp.66-75
摘要:Abstract(#br)Fluorescently labeled proteins that are found both in the cytoplasm and at the plasma membrane, such as peripheral membrane proteins, create stratified fluorescent layers that present a challenging environment for brightness studies with fluorescence fluctuation spec...
作者:Elizabeth M. Smith , Steve Sorota ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2010, Vol.20 (15), pp.4602-4606
摘要:Abstract(#br)A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca V 3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the p...

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