全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Eliza Wiercinska , Ariane Krämer ...
来源:[J].Journal of Translational Medicine(IF 3.459), 2017, Vol.15 (1)Springer
摘要:Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing mobilization with a peptidic CXCR4 antagonist POL6326 (balixafortide) ...
作者:Eliza Wiercinska , Marja JM van der Burg ...
来源:[J].Molecular Cancer(IF 5.134), 2011, Vol.10 (1)Springer
摘要:Abstract(#br) Background(#br)In around 50% of all human cancers the tumor suppressor p53 is mutated. It is generally assumed that in the remaining tumors the wild-type p53 protein is functionally impaired. The two main inhibitors of p53, hMDM2 (MDM2) and hMDMX (MDMX/MDM4) are fre...
作者:Eliza Wiercinska , A. M. Gressner ...
来源:[J].Journal of Cellular and Molecular Medicine(IF 4.753), 2006, Vol.10 (4), pp.922-932Wiley
摘要:Abstract(#br)Background/Aims: Profibrogenic TGF‐β signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF‐β effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenes...
作者:Eliza Wiercinska , Amina F. A. S. Teunisse ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2014, Vol.148 (1), pp.7-18Springer
摘要:Abstract(#br)The p53 tumor suppressor protein is primarily known for its important role in tumor suppression. In addition, p53 affects tumor cell migration, invasion, and epithelial-mesenchymal transition (EMT); processes also regulated by the transforming growth factor-β (T...
作者:Eliza Wiercinska , Benjamin Tast ...
来源:[J].Experimental Hematology(IF 2.907), 2019, Vol.78, pp.35-45Elsevier
摘要:Endocannabinoids are lipid mediators that signal via several seven-transmembrane domain G protein-coupled receptors. The endocannabinoid receptor CB2 is expressed on blood cells, including stem cells, and mediates the effects of cannabinoids on the immune system. The role of...
作者:Eliza Wiercinska , Valerie Barbier ...
来源:[J].Experimental Hematology(IF 2.907), 2016, Vol.44 (4), pp.303-314.e1Elsevier
摘要:Harvest of granulocyte colony-stimulating factor (G-CSF)-mobilized hematopoietic stem cells (HSCs) begins at day 5 of G-CSF administration, when most donors have achieved maximal mobilization. This is based on surrogate markers for HSC mobilization, such as CD34 + cells and ...
作者:Eliza Wiercinska , Darja Karpova ...
来源:[J].Cytotherapy(IF 3.055), 2015, Vol.17 (10), pp.1465-1471Elsevier
摘要:Abstract(#br)Background aims(#br)Immunomagnetic enrichment of CD34+ hematopoietic “stem” cells (HSCs) using paramagnetic nanobead coupled CD34 antibody and immunomagnetic extraction with the CliniMACS plus system is the standard approach to generating T-cell-depleted stem ce...
作者:Eliza Wiercinska , Hildegonda P. H. Naber ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2011, Vol.128 (3), pp.657-666Springer
摘要:Abstract(#br)Transforming growth factor-β (TGF-β) has opposing roles in breast cancer progression by acting as a tumor suppressor in the initial phase, but stimulating invasion and metastasis at later stages. In contrast to the mechanisms by which TGF-β induces growth arrest...

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