全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Dykema Karl , Chen Jindong ...
来源:[J].BMC Medical Genomics(IF 3.466), 2010, Vol.3 (1), pp.59DOAJ
摘要:Abstract Background Germline mutations in the folliculin ( FLCN ) gene are associated with the development of Birt-Hogg-Dubé syndrome (BHDS), a disease characterized by papular skin lesions, a high occurrence of spontaneous pneumothorax, and the development of renal neoplasi...
作者:Dykema Karl , Ho Coral
来源:[J].BMC Genomics(IF 4.397), 2005, Vol.6 (1), pp.67DOAJ
摘要:Abstract Background Regional expression biases (REBs) are genetic intervals where gene expression is coordinately changed. For example, if a region of the genome is amplified, often the majority of genes that map within the amplified region show increased expression when compared...
作者:Dykema Karl , Cao Brian ...
来源:[J].Journal of Translational Medicine(IF 3.459), 2008, Vol.6 (1), pp.77DOAJ
摘要:Abstract Animal models greatly facilitate understanding of cancer and importantly, serve pre-clinically for evaluating potential anti-cancer therapies. We developed an invasive orthotopic human glioblastoma multiforme (GBM) mouse model that enables real-time tumor ultrasound imag...
作者:Dykema Karl , Zhao Ping ...
来源:[J].Kidney international, 2015, Vol.88 (5), pp.1057-69PubMed
摘要:The study of kidney cancer pathogenesis and its treatment has been limited by the scarcity of genetically defined animal models. The FLCN gene that codes for the protein folliculin, mutated in Birt-Hogg-Dubé syndrome, presents a new target for mouse modeling of kidney cancer...
作者:Dykema Karl , Johnson Jennifer ...
来源:[J].Genes & cancer, 2013, Vol.4 (7-8), pp.247-60PubMed
摘要:Hepatitis B virus (HBV) is a well-known cause of hepatocellular carcinoma (HCC), but the regulators effectively driving virus production and HCC progression remain unclear. By using genetically engineered mouse models, we show that overexpression of hepatocyte growth factor (HGF)...
作者:Dykema Karl , Essenberg Curt ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America, 2016, Vol.113 (51), pp.14793-14798PubMed
摘要:Chromosome instability (CIN) is the most striking feature of human cancers. However, how CIN drives tumor progression to metastasis remains elusive. Here we studied the role of chromosome content changes in generating the phenotypic dynamics that are required for metastasis. We i...
作者:Dykema Karl , Rioux-Leclercq Nathalie ...
来源:[J].The Journal of pathology, 2012, Vol.227 (2), pp.146-56PubMed
摘要:Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney cancer. Here, we integrated an unbiased genome-wide RNA interference screen for ccRCC survival regulators with an analysis of recurrently overexpressed genes in ccRCC to identify new therape...

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