全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Douglas A. Lauffenburger , Herwig Strik
来源:[J].Fluids and Barriers of the CNS, 2017, Vol.14 (1)Springer
摘要:Neoplastic invasion into leptomeninges and subarachnoid space, resulting in neoplastic meningitis (NM) is a fatal complication of advanced solid and hematological neoplasms. Identification of malignant involvement of the cerebrospinal fluid (CSF) early in the disease course ...
作者:... Alan Wells , Linda G. Griffith , Douglas A. Lauffenburger
来源:[J].Biomaterials(IF 7.604), 2011, Vol.32 (30), pp.7524-7531Elsevier
摘要:Abstract(#br)Biomimetic scaffolds have been proposed as a means to facilitate tissue regeneration by multi-potent stromal cells (MSCs). Effective scaffold colonization requires a control of multiple MSC responses including survival, proliferation, differentiation, and migrat...
作者:Douglas A. Lauffenburger , Kenneth D. Westover ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2016Elsevier
摘要:Abstract(#br)Targeted polypharmacology provides an efficient method of treating diseases such as cancer with complex, multigenic causes provided that compounds with advantageous activity profiles can be discovered. Novel covalent TAK1 inhibitors were validated in cellular context...
作者:... George Poulogiannis , Douglas A. Lauffenburger , Claus Jørgensen
来源:[J].Cell(IF 31.957), 2016, Vol.165 (4), pp.910-920Elsevier
摘要:Summary(#br)Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS G12D ) also regulates tumor cell signaling via stromal cells. By combining cell-specific proteome labeling with multivariate phosphoprote...
作者:Douglas A. Lauffenburger , Linda G. Griffith
来源:[J].Drug Discovery Today(IF 6.551), 2014, Vol.19 (6), pp.754-762Elsevier
摘要:Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell te...
作者:... Shuguang Zhang , Roger D. Kamm , Douglas A. Lauffenburger
来源:[J].Biomaterials(IF 7.604), 2002, Vol.23 (1), pp.219-227Elsevier
摘要:Abstract(#br)In order to elucidate design principles for biocompatible materials that can be created by in situ transformation from self-assembling oligopeptides, we investigate a class of oligopeptides that can self-assemble in salt solutions to form three-dimensional matri...
作者:... Bruce Tidor , Douglas A. Lauffenburger , Michael T. Hemann
来源:[J].Cell(IF 31.957), 2016, Vol.165 (1), pp.234-246Elsevier
摘要:Summary(#br)The prevailing approach to addressing secondary drug resistance in cancer focuses on treating the resistance mechanisms at relapse. However, the dynamic nature of clonal evolution, along with potential fitness costs and cost compensations, may present exploitable...

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