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作者:... Kaylee D. Dimeo , Tiegang Tong , Donna M. Peters
来源:[J].Experimental Eye Research(IF 3.026), 2017Elsevier
摘要:Abstract(#br)Fibronectin fibrils are a major component of the extracellular matrix (ECM) of the trabecular meshwork (TM). They are a key mediator of the formation of the ECM which controls aqueous humor outflow and contributes to the pathogenesis of glaucoma. The purpose of this ...
作者:Donna M. Peters , Nathan Dowd ...
来源:[J].In Vitro Cellular & Developmental Biology - Animal(IF 1.289), 1996, Vol.32 (5), pp.279-284Springer
摘要:Summary(#br)Human corneal fibroblasts were infected with a retroviral delivery vector containing the E6 and E7 genes from human Papilloma virus type 16 in order to produce cell lines that have an expanded lifespan in culture. Morphologically, some of the trasfected corneal f...
作者:... Bianca R. Tomasini-Johansson , Donna M. Peters , Glen S. Kwon
来源:[J].Pharmaceutical Research(IF 4.742), 2018, Vol.35 (7), pp.1-10Springer
摘要:Abstract(#br) Purpose(#br)To develop PEGylated variants of pUR4/FUD (FUD), a fibronectin assembly inhibitor, using 10 kDa, 20 kDa, and 40 kDa PEGs to evaluate their binding affinity and inhibitory potency.(#br) Methods(#br)The FUD peptide was recombinantly expressed, purified, an...
作者:... Ross W. Clark , Mark S. Filla , Donna M. Peters
来源:[J].Experimental Eye Research(IF 3.026), 2015, Vol.130, pp.9-16Elsevier
摘要:Abstract(#br)Mutations in the myocilin gene ( MYOC ) account for 10% of juvenile open-angle glaucoma cases and 3–4% of adult onset primary open-angle glaucoma cases. It is a secreted glycoprotein found in many ocular and non-ocular tissues and has been linked to elevated int...
作者:... Jennifer A. Faralli , Jennifer L. Peotter , Donna M. Peters
来源:[J].Experimental Eye Research(IF 3.026), 2016, Vol.158Elsevier
摘要:Abstract(#br)Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). In addition to their role as adhesion receptors, integrins can act as ‘‘bidirectional signal transducers’’ that coordinate a large numbe...
作者:... Kaylee Dimeo , Jose M. Gonzalez , Donna M. Peters
来源:[J].Experimental Cell Research(IF 3.557), 2016, Vol.347 (2), pp.301-311Elsevier
摘要:Abstract(#br)We previously demonstrated that an αvβ5 integrin/FAK- mediated pathway regulated the phagocytic properties of human trabecular meshwork (HTM) cells. Here we demonstrate that this process is mediated by Rac-1 and a previously unreported signaling pathway that uti...
作者:Donna M. Peters , Kathleen Herbert ...
来源:[J].Experimental Cell Research(IF 3.557), 2004, Vol.303 (2), pp.218-228Elsevier
摘要:Abstract(#br)Myocilin, a novel matricellular protein found in the human eye, can modify signaling events mediated by the Heparin II domain of fibronectin. Using myocilin produced in sf9 insect cells, myocilin inhibited spreading of cycloheximide-treated human skin fibroblast...
作者:Mark S. Filla , Ross Clark , Donna M. Peters
来源:[J].Experimental Cell Research(IF 3.557), 2014, Vol.327 (2), pp.171-182Elsevier
摘要:Abstract(#br)In this study, we examined the role(s) of syndecan-4 in regulating the formation of an actin geodesic dome structure called a cross-linked actin network (CLAN) in which syndecan-4 has previously been localized. CLANs have been described in several different cell...
作者:... Mark S. Filla , Tania N. Crotti , Donna M. Peters
来源:[J].BBA - Molecular Cell Research(IF 4.808), 2013, Vol.1833 (12), pp.3306-3313Elsevier
摘要:Abstract(#br)The purpose of this study was to determine how dexamethasone (DEX) regulates the expression and activity of αvβ3 integrin. FACS analysis showed that DEX treatment induced expression of an activated αvβ3 integrin. Its expression remained high as long as DEX was p...
作者:... B’Ann T. Gabelt , Donna M. Peters , Paul L. Kaufman
来源:[J].Experimental Eye Research(IF 3.026), 2010, Vol.91 (4), pp.486-490Elsevier
摘要:Abstract(#br)Sodium orthovanadate (Na 3 VO 4 ) is reported to reduce IOP by affecting aqueous formation, but whether it also affects outflow facility (OF) is unclear. We tested the effect of Na 3 VO 4 on OF and intraocular pressure (IOP) in live cynomolgus monkeys, and on ac...

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