全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Donavan T. Cheng , Meera Prasad ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)Springer
摘要:The growing number of Next Generation Sequencing (NGS) tests is transforming the routine clinical diagnosis of hereditary cancers. Identifying whether a cancer is the result of an underlying disease-causing mutation in a cancer predisposition gene is not only diagnostic for a can...
作者:Donavan T. Cheng , Talia N. Mitchell ...
来源:[J].The Journal of Molecular Diagnostics(IF 3.952), 2015, Vol.17 (3), pp.251-264Elsevier
摘要:The identification of specific genetic alterations as key oncogenic drivers and the development of targeted therapies are together transforming clinical oncology and creating a pressing need for increased breadth and throughput of clinical genotyping. Next-generation sequencing a...
作者:Donavan T. Cheng , Janice Cheng ...
来源:[J].The Journal of Molecular Diagnostics(IF 3.952), 2014, Vol.16 (5), pp.504-518Elsevier
摘要:Amplicon-based methods for targeted resequencing of cancer genes have gained traction in the clinic as a strategy for molecular diagnostic testing. An 847-amplicon panel was designed with the RainDance DeepSeq system, covering most exons of 28 genes relevant to acute myeloid leuk...
作者:Donavan T. Cheng , Paul Sabbatini ...
来源:[J].Drug Discovery Today(IF 6.551), 2015, Vol.20 (12), pp.1422-1428Elsevier
摘要:Implementing a center-wide precision medicine strategy at a major cancer center is a true multidisciplinary effort and requires comprehensive alignment of a broad screening strategy with a clinical research enterprise that can use these data to accelerate development of new ...
作者:Donavan T. Cheng , Ryma Benayed ...
来源:[J].The Journal of Molecular Diagnostics(IF 3.952), 2016Elsevier
摘要:Establishing ERBB2 [human epidermal growth factor receptor 2 (HER2)] amplification status in breast and gastric carcinomas is essential to patients' treatment plans. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) constitute the current standard for ...
作者:Donavan T. Cheng , Cynthia Ma ...
来源:[J].The Journal of Allergy and Clinical Immunology(IF 12.047), 2013, Vol.132 (2), pp.455-462Elsevier
摘要:Background(#br)Thymic stromal lymphopoietin (TSLP) pathway blockade is a potential strategy for asthma treatment because the main activities of TSLP are activation of myeloid dendritic cells (mDCs) and modulation of cytokine production by mast cells. TSLP-activated mDCs prim...
作者:Donavan T. Cheng , Meera Prasad ...
来源:[J].2017, Vol.10 (1), pp.33BMC
摘要:The growing number of Next Generation Sequencing (NGS) tests is transforming the routine clinical diagnosis of hereditary cancers. Identifying whether a cancer is the result of an underlying disease-causing mutation in a cancer predisposition gene is not only diagnostic for a can...
作者:Donavan T. Cheng , Marc Ladanyi ...
来源:[J].Genes, Chromosomes and Cancer(IF 3.546), 2015, Vol.54 (8), pp.463-471Wiley
摘要:Melanotic Schwannomas (MS) are rare tumors that share histological features with melanocytic tumors and schwannomas. However, their genetics are poorly understood. To elucidate the genetic characteristics of MS, we performed genome‐wide studies in a series of cases. Twelve M...

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