全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Donatella Granchi , Elena Torreggiani ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.12 (7)DOAJ
摘要:The extracellular acidic milieu in bones results in activation of osteoclasts (OC) and inhibition of osteoblasts (OB) causing a net loss of calcium from the skeleton and the deterioration of bone microarchitecture. Alkalinization through supplementation with potassium citrate (K ...
作者:... Shigekuni Hosogi , Donatella Granchi , Nicola Baldini
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (10)DOAJ
摘要:Rhabdomyosarcoma is the most frequent soft tissue sarcoma in children and adolescents, with a high rate of relapse that dramatically affects the clinical outcome. Multiagent chemotherapy, in combination with surgery and/or radiation therapy, is the treatment of choice. Howev...
作者:DONATELLA Granchi , GABRIELA CIAPETTI ...
来源:[J].Cytotherapy(IF 3.055), 2019, Vol.21 (8), pp.870-885Elsevier
摘要:Abstract(#br)Background(#br)Safety and feasibility of a regenerative strategy based on the use of culture-expanded mesenchymal stromal cells (MSCs) have been investigated in phase 2 trials for the treatment of nonunion and osteonecrosis of the femoral head (ONFH). As part of...
作者:Donatella Granchi , Gabriela Ciapetti ...
来源:[J].Biomaterials(IF 7.604), 1999, Vol.20 (12), pp.1079-1086Elsevier
摘要:Abstract(#br)The aim of this study was the evaluation of the release of bone-resorbing cytokines in peripheral blood mononuclear cells (PBMC) of patients with aseptic loosening of Co–Cr hip prostheses. TNF- α , IL-6, and GM-CSF were measured in both unstimulated and PHA-stim...
作者:Donatella Granchi , Elisabetta Verri ...
来源:[J].Biomaterials(IF 7.604), 1998, Vol.19 (1), pp.283-291Elsevier
摘要:Abstract(#br)We have evaluated the effects of chromiuim extract on the release by peripheral blood mononuclear cells (PBMCs) of cytokines favouring bone resorption. Furthermore, we have evaluated whether the chromium effects could be correlated with the activation and prolif...
作者:Donatella Granchi , Gabriela Ciapetti ...
来源:[J].Biomaterials(IF 7.604), 2000, Vol.21 (17), pp.1789-1795Elsevier
摘要:Abstract(#br)The authors evaluated the ability of bone cement to modify the profile of pro-inflammatory cytokines secreted by the immune cells. Peripheral blood mononuclear cells (PBMC) collected from healthy individuals were cultured with cement extracts and tested to asses...
作者:Donatella Granchi , Ilaria Amato ...
来源:[J].Biomaterials(IF 7.604), 2005, Vol.26 (15), pp.2371-2379Elsevier
摘要:Abstract(#br)In this study, we investigate the molecular mechanisms by which human osteoblasts (HOB) challenged with wear debris promote the differentiation of osteoclast precursors. HOB were obtained from trabecular bone and exposed to alumina (Al 2 O 3 ) or ‘ultra-high mol...
作者:Donatella Granchi , Gabriela Ciapetti ...
来源:[J].Biomaterials(IF 7.604), 2002, Vol.23 (4), pp.1033-1041Elsevier
摘要:Abstract(#br)The aim of the study was to evaluate some aspects of the immunocompatibility of 10 acrylic bone cements. Mononuclear cells harvested from healthy individuals were cultured with cement extracts which were tested to assess their effect on the viability of lymphocy...
作者:Donatella Granchi , Elisabetta Cenni ...
来源:[J].Biomaterials(IF 7.604), 2002, Vol.23 (11), pp.2359-2365Elsevier
摘要:Abstract(#br)The osteoprotegerin-ligand (OPG-L) has been identified as the essential factor required for osteoclastogenesis, and its effects are prevented by the osteoprotegerin (OPG). The OPG-L/OPG balance plays a crucial role in coordinating the sequence of osteoclast and ...

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