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作者:Dimitrios Gatos , Stefan Arenz
来源:[J].Amino Acids(IF 3.914), 2017, Vol.49 (5), pp.995-1004
摘要:Chloramphenicol peptides were recently established as useful tools for probing nascent polypeptide chain interaction with the ribosome, either biochemically, or structurally. Here, we present a new 10mer chloramphenicol peptide, which exerts a dual inhibition effect on the riboso...
作者:Dimitrios Gatos , Theodore Tselios ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.101, pp.13-23
摘要:Abstract(#br)Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system, and it has been established that autoreactive T helper (Th) cells play a crucial role in its pathogenesis. Myelin basic protein (MBP) epitopes are major autoantigens...
作者:Spyros Mourtas , Dimitrios Gatos , Kleomenis Barlos
来源:[J].Tetrahedron Letters(IF 2.397), 2001, Vol.42 (11), pp.2201-2204
摘要:Abstract(#br)2-Aminobenzenethiol, bound through its thiol function to the 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)- and 4-methoxytrityl (Mmt)-resins, was acylated at the amino-function by aliphatic and aromatic acids. The obtained 2- N -acyl-aminobenzenethi...
作者:Dimitrios Gatos , Vagiani Kalaitzi ...
来源:[J].Tetrahedron Letters(IF 2.397), 2001, Vol.42 (39), pp.6965-6967
摘要:Abstract(#br)4-Methoxytrityl (Mmt)-mercapto acids were obtained either by the reaction of mercapto acids with Mmt-chloride or by the reaction of halo acids with Mmt-thiol. The derivatives obtained were used in the solid-phase synthesis of small libraries of mercaptoacylamino acid...
作者:Dimitrios Gatos , Olga Hatzi
来源:[J].Tetrahedron Letters(IF 2.397), 1995, Vol.36 (31), pp.5645-5648
摘要:Abstract(#br)Fmoc/tBu-protected peptides, synthesized on 2-chlorotrityl resin (CLTR), have been quantitatively esterified by treatment with 2-chlorotrityl chloride (Clt-chloride) and diisopropylethylamine (DIPEA). The obtained peptide Clt-esters have been deprotected at the ...
作者:Dimitrios Gatos , Manolis Karavoltsos ...
来源:[J].Tetrahedron Letters(IF 2.397), 2002, Vol.43 (18), pp.3419-3421
摘要:Abstract(#br)Mercapto acids were attached through their thiol group onto 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)-, 4-methoxytrityl (Mmt)- and 4,4′-dimethoxytrityl (Dmt)-resins. The new resins were used in the solid-phase synthesis of small mercaptoacylamin...
作者:... Spyros Mourtas , Dimitrios Gatos , Kleomenis Barlos
来源:[J].Tetrahedron Letters(IF 2.397), 2003, Vol.44 (20), pp.3979-3982
摘要:Abstract(#br)Diamines derived from naturally occurring aminoacids were inserted into peptide chains by the reaction of the monophthaloyl diamines with amino acid 1-benzotriazolyl esters, bound through their amino functions onto trityl-type resins. The phthaloyl group was removed ...
作者:... Chryssoula Tzavara , Dimitrios Gatos , Kleomenis Barlos
来源:[J].Tetrahedron Letters(IF 2.397), 2003, Vol.44 (1), pp.179-182
摘要:Abstract(#br)Aminothiols were attached through their thiol group onto the 4,4′-dimethoxytrityl (Dmt)-, 4-methoxytrityl (Mmt)-, 4-methyltrityl (Mtt)-, trityl (Trt)- and 2-chlorotrityl (Clt)-resins. The new resins were used in the solid-phase synthesis of aminothiol containing...
作者:Dimitrios Gatos , Antonis Panagopoulos ...
来源:[J].Tetrahedron Letters(IF 2.397), 1999, Vol.40 (14), pp.2825-2828
摘要:Abstract(#br)Histidine, histamine and urocanic acid were attached through the N im -function on resins of the trityl type. The conditions of the cleavage of these derivatives from the resin were determined. Resin bound histamine was used in the solid phase synthesis of carcinine.
作者:Dimitrios Gatos , John Matsoukas
来源:[J].Amino Acids(IF 3.914), 2011, Vol.40 (5), pp.1431-1440
摘要:Abstract(#br)A fast and efficient microwave-assisted solid phase peptide synthesis (MW-SPPS) of a 51mer peptide, the main heparin-binding site (60–110) of human pleiotrophin (hPTN), using 2-chlorotrityl chloride resin (CLTR-Cl) following the 9-fluorenylmethyloxycarbonyl/ ter...

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