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作者:Diego Pereira Sangi , Arlene Gonçalves Corrêa ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2018
摘要:Abstract(#br)Continuous efforts have been made to discover new drugs for the treatment of Chagas’ disease, human African trypanosomiasis, and leishmaniasis. We have previously reported the synthesis and antileishmanial and antitrypanosomal (Y strain) properties of 2,3-disubs...
作者:Diego Pereira Sangi
来源:[J].Química Nova, 2017, Vol.39 (8), pp.995-1006
摘要:Drug discovery often involves screening synthetic small molecules for their ability to bind to a macromolecular target. Target-Oriented Synthesis of a specific compound or a focused library can be planned combining retrosynthetic analysis and rational drug design. Biologically ac...
作者:... Arlene Gonçalves Corrêa , Diego Pereira Sangi , Celso Vataru Nakamura
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.9 (1)
摘要:Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is considered endemic. The chemotherapy for Chagas disease remains a problem; the standard treatment currently relies on a single drug, benzn...
作者:Diego Pereira Sangi , Tânia Ueda-Nakamura ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.90, pp.107-123
摘要:Abstract(#br)Quinoxalines belong to the N -containing heterocyclic compounds that stand out as having promising biological activity due to their privileged scaffold. In this work, we report the synthesis, antileishmanial, and antitrypanosomal properties of 46 new 2,3-disubst...
作者:... Arlene Gonçalves Corrêa , Diego Pereira Sangi , Celso Vataru Nakamura
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (1)
摘要:Chagas’ disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is considered endemic. The chemotherapy for Chagas disease remains a problem; the standard treatment currently relies on a single drug, ...

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