全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Dennis W. Wolff , Yan Xie ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Virtually all prostate cancer deaths occur due to obtaining the castration-resistant phenotype after prostate cancer cells escaped from apoptosis and/or growth suppression initially induced by androgen receptor blockade. TNF-related apoptosis-inducing ligand (TRAIL) was an attrac...
作者:Dennis W. Wolff , Stephen Rennard ...
来源:[J].Respiratory Research(IF 3.642), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)Pirfenidone was recently approved for treatment of idiopathic pulmonary fibrosis. However, the therapeutic dose of pirfenidone is very high, causing side effects that limit its doses and therapeutic effectiveness. Understanding the molecular mechanism...
作者:Dennis W. Wolff , Myron L. Toews
来源:[J].Biochemical Pharmacology(IF 4.576), 2013, Vol.85 (10), pp.1454-1462Elsevier
摘要:Abstract(#br)Metastasis is the major cause of breast cancer mortality. We recently reported that aberrant G-protein coupled receptor (GPCR) signaling promotes breast cancer metastasis by enhancing cancer cell migration and invasion. Phosphatidylinositol 3-kinase γ (PI3Kγ) is...
作者:Dennis W. Wolff , Peter W. Abel ...
来源:[J].The Journal of Allergy and Clinical Immunology(IF 12.047), 2012, Vol.130 (4), pp.968-976.e3Elsevier
摘要:Background(#br)Drugs targeting individual G protein–coupled receptors are used as asthma therapies, but this strategy is limited because of G protein–coupled receptor signal redundancy. Regulator of G protein signaling 2 (RGS2), an intracellular selective inhibitor of multip...
作者:Dennis W. Wolff , Peter W. Abel
来源:[J].FEBS Letters(IF 3.582), 2010, Vol.584 (22), pp.4570-4574Elsevier
摘要:Abstract(#br)Regulator of G-protein signaling 4 (RGS4), an intracellular modulator of G-protein coupled receptor (GPCR)-mediated signaling, is regulated by multiple processes including palmitoylation and proteasome degradation. We found that co-expression of DHHC acyltransfe...
作者:Dennis W. Wolff , Scott A. Rollins
来源:[J].Journal of Immunological Methods(IF 2.225), 1995, Vol.184 (1), pp.123-138Elsevier
摘要:Abstract(#br)Inhibition of complement system activation requires the development of soluble nonimmunogenic inhibitors with good tissue penetrating abilities that are themselves unable to activate complement. Chimeric mouse/human Fabs capable of blocking the activity of complement...
作者:Dennis W. Wolff , Yan Xie ...
来源:[J].International Journal of Cancer(IF 6.198), 2012, Vol.130 (7), pp.1521-1531Wiley
摘要:Abstract(#br)G‐protein‐coupled receptor (GPCR)‐stimulated androgen‐independent activation of androgen receptor (AR) contributes to acquisition of a hormone‐refractory phenotype by prostate cancer. We previously reported that regulator of G‐protein signaling (RGS) 2...

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