全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Denis Guilloteau , Louisa Barré
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (9)DOAJ
摘要:In quantitative PET measurements, the analysis of radiometabolites in plasma is essential for determining the exact arterial input function. Diphenyl sulfide compounds are promising PET and SPECT radioligands for in vivo quantification of the serotonin transporter (SERT) and...
作者:Denis Guilloteau , Claire Tronel
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2017, Vol.18 (4)DOAJ
摘要:In vivo exploration of activated microglia in neurodegenerative diseases is achievable by Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals targeting the translocator protein-18 kDa (TSPO). In this review, we emphasized the major advances made ...
作者:Denis Guilloteau , Guylene Page ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2019, Vol.179, pp.449-469Elsevier
摘要:Abstract(#br)In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron derivatives. The ...
作者:Denis Guilloteau , Stéphanie Egret ...
来源:[J].Alzheimer's & Dementia: The Journal of the Alzheimer's Association(IF 14.483), 2016Elsevier
摘要:Abstract(#br)Introduction(#br)Subjective cognitive decline (SCD) could indicate preclinical Alzheimer's disease, but the existing literature is confounded by heterogeneous approaches to studying SCD. We assessed the differential cognitive, affective, and neuroimaging correla...
作者:Denis Guilloteau , Franck Suzenet ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2014, Vol.82, pp.214-224Elsevier
摘要:Abstract(#br)In this report, we describe the synthesis of a novel library of α7 nAChR ligands based on the modulation of the quinuclidine, quinazoline and tropane moieties. Spirane derivatives were newly synthesized under stereo specific 1,3 dipolar cylcoadditions. Only amid...
作者:Denis Guilloteau , Jean-Bernard Deloye ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2014, Vol.41 (1), pp.106-113Elsevier
摘要:Abstract(#br)Introduction(#br)We examined whether [ 18 F]LBT-999 ( (E)-N -(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4’-tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) in the healthy rat brain....
作者:Denis Guilloteau , Michael Kassiou ...
来源:[J].Neurobiology of Aging(IF 6.166), 2015, Vol.36 (4), pp.1639-1652Elsevier
摘要:Abstract(#br)We studied concomitantly the level of neuroinflammation and β-amyloid (Aβ) load in the APPswePS1dE9 transgenic mouse model of Alzheimer's disease using positron emission tomography. The translocator protein 18 kDa (TSPO) tracer [ 18 F]DPA-714 was used to measure...
作者:Denis Guilloteau , Franck Suzenet ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2016, Vol.107, pp.153-164Elsevier
摘要:Abstract(#br)We report here the synthesis of a large library of 1,2,3-triazole derivatives which were in vitro tested as α7 nAchR ligands. The SAR study revealed that several crucial factors are involved in the affinity of these compounds for α7 nAchR such as a ( R ) quinucl...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×