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作者:Dean P. Edwards , Viroj Boonyaratanakornkit
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2020, Vol.199Elsevier
摘要:Abstract(#br)Progesterone receptor (PR) is expressed in a wide variety of human tissues, including both reproductive and non-reproductive tissues. Upon binding to the PR, progesterone can display several non-reproductive functions, including neurosteroid activity in the central n...
作者:Dean P. Edwards , Hironobu Sasano
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2019, Vol.190, pp.212-223Elsevier
摘要:Abstract(#br)The progesterone receptor (PR) has been reported to play important roles in lung development and function, such as alveolarization, alveolar fluid clearance (AFC) and upper airway dilator muscle activity. In the lung, pulmonary neuroendocrine cells (PNECs) are import...
作者:Dean P. Edwards , Stuart J. Corr ...
来源:[J].Biomaterials(IF 7.604), 2016, Vol.108, pp.129-142Elsevier
摘要:Abstract(#br)Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease. Therefore, greater understanding of the stroma development and tumor-stroma interactions is highly r...
作者:Dean P. Edwards , Suzanne E. Wardell , Viroj Boonyaratanakornkit
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2002, Vol.83 (1), pp.173-186Elsevier
摘要:Abstract(#br)Progesterone receptor (PR) is a member of the nuclear receptor family of ligand-dependent transcription activators and is expressed as two different sized proteins from a single gene; PR-A and PR-B. The two PR isoforms are identical in their DNA binding domains (DBD)...
作者:Dean P. Edwards , Magda Altmann ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1995, Vol.53 (1), pp.449-458Elsevier
摘要:Abstract(#br)Currently available progesterone antagonists have been suggested to fall into two categories based on differences in how they interact with and inactivate the progesterone receptor (PR). The anti-progestin ZK98299 (Type I) impairs PR association with DNA, while Type ...
作者:Nicole L. Moore , Dean P. Edwards , Nancy L. Weigel
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2014, Vol.144, pp.471-482Elsevier
摘要:Abstract(#br)A role for the cell cycle protein cyclin A2 in regulating progesterone receptor (PR) activity is emerging. This study investigates the role of cyclin A2 in regulating endogenous PR activity in T47D breast cancer cells by depleting cyclin A2 expression and measuring P...
作者:... Jeannine S. Strobl , Dean P. Edwards , Renee N. Gentry
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1997, Vol.62 (4), pp.243-252Elsevier
摘要:Abstract(#br)Previous reports have shown that progestins stimulate the proliferation of the human breast cancer cell line T47D in culture. Under different conditions other reports have shown progestin stimulation, inhibition or no effect on growth. It has also been shown tha...
作者:Dean P. Edwards , Jeffrey T. Jenkins
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2009, Vol.117 (1), pp.23-30Elsevier
摘要:Abstract(#br)Superoxide dismutase (SOD) occurs in two intracellular forms in mammals, copper–zinc SOD (CuZnSOD), found in the cytoplasm, mitochondria and nucleus, and manganese superoxide dismutase (MnSOD), in mitochondria. Changes in MnSOD expression (as compared to normal ...
作者:... Candace A. Beck , Dean P. Edwards , Angelo Poletti
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1995, Vol.53 (1), pp.509-514Elsevier
摘要:Abstract(#br)Four phosphorylation sites have been identified in the chicken progesterone receptor. Two of these sites exhibit basal phosphorylation which is enhanced upon treatment with hormone and two of the sites are phosphorylated in response to hormone. Mutation of one of the...
作者:... Alice H. Cavanaugh , Dean P. Edwards , S.Stoney Simons
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1998, Vol.67 (3), pp.251-266Elsevier
摘要:Abstract(#br)We previously reported evidence for two subpopulations of several classes of steroid receptors that could be distinguished by their requirement of a low molecular weight factor ( M r =700–3000 Da) for binding to nonspecific, calf thymus DNA–cellulose [Cavanaugh,...

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