全部文献期刊会议图书|学者科研项目
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作者:Dawn R. Cochrane , Megan Fuller ...
来源:[J].Gynecologic Oncology(IF 3.929), 2017, Vol.147 (3), pp.663-671Elsevier
摘要:Abstract(#br)Objective(#br)APELA is a small, secreted peptide that can function as a ligand for the G-protein coupled receptor, Apelin Receptor (APLNR, APJ). APELA plays an essential role in endoderm differentiation and cardiac development during embryogenesis. We investigated wh...
作者:Dawn R. Cochrane , Jamie L.P. Lim ...
来源:[J].Cell(IF 31.957), 2018, Vol.173 (7), pp.1755-1769.e22Elsevier
摘要:Summary(#br)High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We investigated whether local immune microenvironment factors shape tumor progression properties at the interface of...
作者:Dawn R. Cochrane , Michael S. Anglesio ...
来源:[J].Gynecologic Oncology(IF 3.929), 2017, Vol.147 (3), pp.642-647Elsevier
摘要:Abstract(#br)Objective(#br)Endometrioid (ENOC) and clear cell ovarian carcinoma (CCOC) share a common precursor lesion, endometriosis, hence the designation endometriosis associated ovarian cancers (EAOC). Long interspersed nuclear element 1 (LINE-1 or L1), is a family of mo...
作者:Dawn R. Cochrane , Basile Tessier-Coutier ...
来源:[J].Human Pathology(IF 2.843), 2019, Vol.92, pp.39-47Elsevier
摘要:Summary(#br)LINE-1 (L1) retrotransposons are mobile genetic elements capable of “copy-and-pasting” their own sequences into random genomic loci, and one of the proteins it uses to achieve mobility is LINE-1 open reading frame 1 protein (L1ORF1p). L1ORF1p expression is found ...
作者:Dawn R. Cochrane , Nicole S. Spoelstra , Jennifer K. Richer
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.50-59Elsevier
摘要:Abstract(#br)Small non-coding RNAs termed microRNAs (miRNAs) are mediators of post-transcriptional gene silencing and are involved in all aspects of cell biology. Progesterone receptors (PR) are intimately involved in the normal physiology and diseases of hormone responsive tissu...
作者:Dawn R. Cochrane , Diana M. Cittelly , Jennifer K. Richer
来源:[J].Steroids(IF 2.803), 2010, Vol.76 (1), pp.1-10Elsevier
摘要:Abstract(#br)MicroRNAs (miRNAs) are small non-coding RNAs that serve as post-transcriptional regulators of gene expression. They work predominantly by binding to complementary sequences in target messenger RNA (mRNA) 3′ untranslated regions (UTRs) where they prevent translat...
作者:Dawn R. Cochrane , Britta M. Jacobsen ...
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.355 (1), pp.15-24Elsevier
摘要:Abstract(#br)Progesterone receptors (PRs) mediate response to progestins in the normal breast and breast cancer. To determine if liganded PR regulate microRNAs (miRNAs) as a component of their action, we profiled mature miRNA levels following progestin treatment. Indeed, 28 ...
作者:Erin N. Howe , Dawn R. Cochrane , Jennifer K. Richer
来源:[J].Journal of Mammary Gland Biology and Neoplasia(IF 7.524), 2012, Vol.17 (1), pp.65-77Springer
摘要:Abstract(#br)Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. These changes can lead tumor cells to acquire characteristics that enable movement from the primary site of origin when conditions become unfavorable. Such characterist...
作者:Dawn R. Cochrane , Erin N. Howe ...
来源:[J].Journal of Oncology, 2010, Vol.2010DOAJ
摘要:We focus on unique roles of miR-200c in breast, ovarian, and endometrial cancers. Members of the miR-200 family target ZEB1, a transcription factor which represses E-cadherin and other genes involved in polarity. We demonstrate that the double negative feedback loop between miR-2...

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