全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Davide Bello , David O'Hagan
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2015, Vol.11 (1), pp.1902-1909DOAJ
摘要:A new method for the preparation of α-fluorovinyl thioethers is reported which involves the hydrofluorination of alkynyl sulfides with 3HF·Et3N, a process that requires Lewis acid activation using BF3·Et2O and TiF4. The method give...
作者:... David B. Cordes , Alexandra M. Z. Slawin , David O'Hagan
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2015, Vol.11 (1), pp.2671-2676DOAJ
摘要:Palladium catalysed carbonylation reactions using the meta - and para -iodo derivatives of all- cis- 3-phenyl-1,2,4,5-tetrafluorocyclohexane ( 4 ) are illustrated as the start point for a variety of functional group interconversions. The resultant benzaldehyde and benzoic acids o...
作者:David O'Hagan , Alexandra M. Z. Slawin , Václav Jurčík
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2011, Vol.7 (1), pp.759-766DOAJ
摘要:The first synthesis of α-(trifluoromethyl)-β-lactam (( S )- 1 ) is reported. The route starts from α-(trifluoromethyl)acrylic acid ( 2 ). Conjugate addition of α-( p -methoxyphenyl)ethylamine (( S )- 3b ), generated an addition adduct 4b which was cyclised to β-lactam 5...
作者:... Ian N. Fleming , Nigel P. Botting , David O'Hagan
来源:[J].Tetrahedron(IF 2.803), 2014, Vol.70 (44), pp.8343-8347Elsevier
摘要:Abstract(#br)A series of analogues of the integrin binding aspartic acid-glycine-arginine (RGD) peptide sequence were synthesised conjugated to nitric oxide (NO) donating functional groups. Also the cytotoxicity of abiraterone, a prostate cancer drug, was explored when it was con...
作者:... Peer Kirsch , Alexandra M.Z. Slawin , David O'Hagan
来源:[J].Tetrahedron(IF 2.803), 2014, Vol.70 (31), pp.4626-4630Elsevier
摘要:Abstract(#br)A protocol for the preparation of a series of liquid crystals is presented, where the structures carry a central propyleneoxy motif carrying two vicinal threo -C–F bonds. The negative dielectric anisotropy (−Δ ɛ ) of the resultant liquid crystals has been e...

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