全部文献期刊会议图书|学者科研项目
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作者:David M. Irwin , Weiwei Zhai
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)
摘要:East Asian dog breeds are one of the most ancient groups of dogs that radiated after the domestication of the dog and represent the most basal lineages of dog evolution. Among these, the Chow Chow is an ancient breed that embodies very distinct morphological and physiological fea...
作者:Ahmad Al-Salam , David M. Irwin
来源:[J].BMC Evolutionary Biology(IF 3.285), 2017, Vol.17 (1)
摘要:Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3 , has been...
作者:David M. Irwin
来源:[J].Peptides(IF 2.522), 2020, Vol.125
摘要:Abstract(#br)Glucose-dependent insulinotropic polypeptide (GIP) is a product of the Gip gene and acts as an incretin hormone in mammals. Gip is most closely related to the proglucagon ( Gcg ) and Exendin genes and diverged from these very early in vertebrate evolution. In mammals...
作者:David M. Irwin , Svetlana Mojsov
来源:[J].General and Comparative Endocrinology(IF 2.823), 2018, Vol.261, pp.148-165
摘要:Abstract(#br)The teleost fish-specific genome duplication gave rise to a great number of species inhabiting diverse environments with different access to nutrients and life histories. This event produced duplicated gcg genes, gcga and gcgb , for proglucagon-derived peptides, gluc...

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