全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:David Loiselle , Jordi B. Torrelles ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome proteins are highly druggable, and many exis...
作者:David Loiselle , Edna Carter Young ...
来源:[J].Neurotoxicology(IF 2.652), 2006, Vol.27 (6), pp.951-969Elsevier
摘要:Abstract(#br)There is increasing concern over the impact of low-dose exposures to environmental chemicals on children's neurobehavioral function. To determine subtle alterations in children's function, it is necessary to move beyond global measures such as IQ and employ test...
作者:David Loiselle , Donald Wolfgeher ...
来源:[J].Cell Reports, 2015, Vol.12 (6), pp.1006-1018Elsevier
摘要:Summary(#br)The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity, tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms d...
作者:David Loiselle , Rachid Safi ...
来源:[J].Journal of Biological Chemistry(IF 4.651), 2015, Vol.290 (29), pp.17985-17998Duke University Press
摘要:Pregnancy promotes physiological adaptations throughout the body, mediated by the female sex hormones progesterone and estrogen. Changes in the metabolic properties of skeletal muscle enable the female body to cope with the physiological challenges of pregnancy and may also ...
作者:David Loiselle , David A. Carlson ...
来源:[J].Cell Chemical Biology, 2016, Vol.23 (6), pp.678-688Elsevier
摘要:Summary(#br)Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty acid synthase (FASN) catalyzes the final synthetic step of this pathway, and its upregulation is correlated with tumor aggressiveness. The consequences and adaptive responses of a...

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