全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:David Gentien , Sabrina Carpentier ...
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.7 (4)DOAJ
摘要:Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the pro...
作者:David Gentien , Jacqueline Lehmann-Che ...
来源:[J].BMC Cancer(IF 3.333), 2011, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)Identification of predictive markers of response to treatment is a major objective in breast cancer. A major problem in clinical sampling is the variability of RNA templates, requiring accurate management of tumour material and subsequent analyses for...
作者:David Gentien , Zofia Maciorowski ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (7)DOAJ
摘要:Drug discovery efforts have focused on the tumor microenvironment in recent years. However, few studies have characterized the stroma component in patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMs). In this study, we characterized the stroma in vario...
作者:David Gentien , Francisco Cruzalegui ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (4)DOAJ
摘要:The canonical Wnt/β-catenin pathway is activated in triple-negative breast cancer (TNBC). The activation of this pathway leads to the expression of specific target genes depending on the cell/tissue context. Here, we analyzed the transcriptome of two different TNBC cell line...
作者:David Gentien , Emmanuel Barillot ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (5)DOAJ
摘要:Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical behavior. No targeted therapy is currently available for the treatment of patients with TNBC. In order to discover potential therapeutic targets, we sear...
作者:... Jean Marc Guinebretiere , Anne Vincent Salomon , David Gentien
来源:[J].New BIOTECHNOLOGY(IF 1.706), 2017Elsevier
摘要:Abstract(#br)The objective of this study was to establish that the denaturing fixative, formalin and acetic acid (AFA), is equivalent to neutral-buffered formalin (NBF) on the nCounter system using the Prosigna assay. Twenty-five previously resected tumors from breast cancer pati...

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