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作者:Dasiel O. Borroto-Escuela , Alexander O. Tarakanov ...
来源:[J].Pharmacological Reports(IF 1.965), 2018Elsevier
摘要:Abstract(#br)The existence of mGluR, NMDAR, AMPAR and putative KAR heteroreceptor complexes in synaptic and extrasynaptic regions of brain glutamate synapses represents a major integrative mechanism. Our aim in the current article is to analyze if the formation of the differ...
作者:Dasiel O. Borroto-Escuela , Alexander O. Tarakanov ...
来源:[J].Pharmacological Reports(IF 1.965), 2018, Vol.70 (7), pp.936-950Springer
摘要:Abstract(#br)The existence of mGluR, NMDAR, AMPAR and putative KAR heteroreceptor complexes in synaptic and extrasynaptic regions of brain glutamate synapses represents a major integrative mechanism. Our aim in the current article is to analyze if the formation of the differ...
作者:Dasiel O. Borroto-Escuela , José Medina-Luque ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2014, Vol.15 (1), pp.1481-1498DOAJ
摘要:The mu opioid receptor (MOR) is critical in mediating morphine analgesia. However, prolonged exposure to morphine induces adaptive changes in this receptor leading to the development of tolerance and addiction. In the present work we have studied whether the continuous admin...
作者:Dasiel O. Borroto-Escuela , Wilber Romero-Fernandez ...
来源:[J].Neurotoxicity Research: Neurodegeneration, Neuroregeneration, Neurotrophic Action, and Neuroprotection(IF 2.865), 2020, Vol.37 (1), pp.433-444Springer
摘要:Abstract(#br)Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (–) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely modulate in...
作者:Dasiel O. Borroto-Escuela , Kjell Fuxe
来源:[J].Neurochemical Research(IF 2.125), 2020, Vol.45 (333), pp.5-15Springer
摘要:Abstract(#br)G protein-coupled receptors modulate the synaptic glutamate and GABA transmission of the claustrum. The work focused on the transmitter–receptor relationships in the claustral catecholamine system and receptor–receptor interactions between kappa opioid receptors...
作者:Dasiel O. Borroto-Escuela , Karolina Wydra ...
来源:[J].Trends in Pharmacological Sciences(IF 9.25), 2018Elsevier
摘要:The concept of allosteric receptor–receptor interactions in G protein-coupled receptor homo- and heteroreceptor complexes in which they physically interact provides a new dimension to molecular integration in the brain. The receptor–receptor interactions dynamically change r...
作者:... José Rejon-Orantes , Dasiel O. Borroto-Escuela , Kjell Fuxe
来源:[J].Neuroscience(IF 3.122), 2019Elsevier
摘要:Abstract(#br)The dopaminergic system integrated by cell groups distributed in several brain regions exerts a modulatory role in brain. Particularly important for this task are the mesencephalic dopamine neurons, which from the substantia nigra and ventral tegmental area proj...
作者:Dasiel O. Borroto-Escuela , Guadalupe Mengod ...
来源:[J].Neuropharmacology(IF 4.114), 2017, Vol.118, pp.233-241Elsevier
摘要:Abstract(#br)The pharmacological treatment of major depression is mainly based on drugs elevating serotonergic (5-HT) activity. Specifically, selective 5-HT reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However...
作者:Dasiel O. Borroto-Escuela , Belén Gago ...
来源:[J].Neuropeptides(IF 2.067), 2017, Vol.64, pp.39-45Elsevier
摘要:Abstract(#br)Galanin is a 29 amino acid neuropeptide widely distributed in neurons within the central nervous system. Galanin exerts its biological activities through three different G protein-receptors and participates in a number of functions, including mood regulation. No...
作者:Dasiel O. Borroto-Escuela , Karolina Wydra ...
来源:[J].Molecular Neurobiology(IF 5.471), 2018, Vol.55 (8), pp.7038-7048Springer
摘要:Abstract(#br)Antagonistic allosteric A2AR-D2R receptor-receptor interactions in heteroreceptor complexes counteract cocaine self-administration and cocaine seeking in rats as seen in biochemical and behavioral experiments. It was shown that the human A2AR transmembrane five (TM5)...

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