全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:... Gilberto Montibeller , Daniel Hochhauser , Panos Kanavos
来源:[J].BMC Medical Informatics and Decision Making(IF 1.603), 2017, Vol.17 (1)
摘要:Multiple criteria decision analysis (MCDA) has appeared as a methodology to address limitations of economic evaluation in health technology assessment (HTA), however there are limited empirical evidence from real world applications. The aim of this study is to test in practice a ...
作者:... John A. Hartley , Clare E. Futter , Daniel Hochhauser
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (1), pp.663-82783
摘要:Abstract(#br)Antibody combinations targeting cell surface receptors are a new modality of cancer therapy. The trafficking and signalling mechanisms regulated by such therapeutics are not fully understood but could underlie differential tumour responses. We explored EGFR trafficki...
作者:Daniel Hochhauser , Hartmut Juhl ...
来源:[J].European Journal of Cancer(IF 5.061), 2017, Vol.84, pp.325-334
摘要:Abstract(#br)The increasing number of drugs targeting specific proteins implicated in tumourigenesis and the commercial promotion of relatively affordable genome-wide analyses has led to an increasing expectation among patients with cancer that they can now receive effective...
作者:... W. David Wilson , Daniel Hochhauser , John A. Hartley
来源:[J].BBA - Gene Regulatory Mechanisms(IF 5.456), 2016
摘要:Abstract(#br)Background(#br)Sequence specific polyamide HxIP 1 , targeted to the inverted CCAAT Box 2 (ICB2) on the topoisomerase IIα ( topo IIα ) promoter can inhibit NF-Y binding, re-induce gene expression and increase sensitivity to etoposide. To enhance biological activi...
作者:Daniel Hochhauser , Moses Lee
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2006, Vol.16 (24), pp.6161-6164
摘要:Abstract(#br)An N -formamido pyrrole- and imidazole-containing triamide (f-PIP) has been shown by DNase I footprinting, SPR, and CD studies to bind as a stacked dimer to its cognate sequences: 5′-TACGAT-3′ (5′-flank of the inverted CCAAT box-2 of the human topoisomerase...
作者:Daniel Hochhauser , Ian D. Hickson
来源:[J].Biochemical Pharmacology(IF 4.576), 1996, Vol.52 (7), pp.1065-1072
摘要:Abstract(#br)Tumor-promoting phorbol esters such as phorbol 12-myristate 13-acetate (PMA) are reported to induce megakaryocyte terminal differentiation of the erythroleukemia cell line K562. This differentiation is accompanied by the regulation of various gene products such ...
作者:Daniel Hochhauser , Moses Lee
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2007, Vol.16 (4), pp.2093-2102
摘要:Abstract(#br)The synthesis and DNA binding characteristics of a polyamide–intercalator conjugate, designed to inhibit NF-Y binding to the ICB-2 site of the topoisomerase IIα promoter and up-regulate the expression of the enzyme in confluent cells, are reported. Thermal denat...
作者:John A Hartley , Daniel Hochhauser
来源:[J].Current Opinion in Pharmacology(IF 5.443), 2012, Vol.12 (4), pp.398-402
摘要:DNA-targeted chemotherapies remain fundamental in clinical management of both common solid tumours and hematologic malignancies. Recent studies indicate that novel combinations of cytotoxic chemotherapy may have significant activity even in tumours regarded as being resistant to ...
作者:Daniel Hochhauser , John A. Hartley
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2010, Vol.18 (15), pp.5553-5561
摘要:Abstract(#br)The synthesis, DNA binding characteristics and biological activity of an N -formamido pyrrole- and imidazole-containing H-pin polyamide (f-PIP H-pin, 2 ) designed to selectively target the ICB2 site on the topoIIα promoter, is reported herein. Thermal denaturati...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×