全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Daisuke Nishizawa , Junko Hasegawa ...
来源:[J].Cancer Chemotherapy and Pharmacology(IF 2.795), 2017, Vol.79 (6), pp.1179-1186Springer
摘要:Whether age and inter-individual variability of pharmacogenetics are risk factors for paclitaxel-induced peripheral neuropathy (PIPN) is inconclusive. This study was conducted to evaluate the influence of previously investigated single nucleotide polymorphisms (SNPs) and age, usi...
作者:Daisuke Nishizawa , Junko Hasegawa ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2015, Vol.127 (3), pp.391-393Elsevier
摘要:Abstract(#br)An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 ( TRPC3 ) gene was suggested by our previous gen...
作者:Daisuke Nishizawa , Shinya Kasai ...
来源:[J].Molecular Brain(IF 4.202), 2015, Vol.8 (1)Springer
摘要:Abstract(#br) Background(#br)Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although several candidate gene variations have been reported by candidate gene studies or genome-wide association studies (GWASs) to be associated with s...
作者:Daisuke Nishizawa , Makoto Nagashima ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (9)DOAJ
摘要:Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK) chan...
作者:Daisuke Nishizawa , Ken-ichi Fukuda ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (8)DOAJ
摘要:Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, lead to different proper doses of fentanyl, which can hamper effective pain treatment. Voltage-activated Ca(2+) channels (VACCs) play a crucial role in the nervous system by controlling membran...
作者:Daisuke Nishizawa , Kazutaka Ikeda ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (10)DOAJ
摘要:The single nucleotide polymorphism (SNP) rs13438494 in intron 24 of PCLO was significantly associated with bipolar disorder in a meta-analysis of genome-wide association studies. In this study, we performed functional minigene analysis and bioinformatics prediction of splicing re...
作者:Daisuke Nishizawa , Tsutomu Mieda ...
来源:[J].Journal of Pain(IF 3.24), 2016, Vol.17 (10), pp.1126-1134Elsevier
摘要:Abstract(#br)Ca v 2.3 (R-type) voltage-activated Ca 2+ channels (VACCs), encoded by the calcium channel, voltage-dependent, R-type, α1E subunit ( CACNA1E ) gene, are responsible for transmission of somatic inflammatory pain, and activation of antinociception elicited by visc...
作者:Daisuke Nishizawa , Shinya Kasai ...
来源:[J].Neuroscience Letters(IF 2.026), 2013, Vol.542, pp.1-4Elsevier
摘要:Abstract(#br)To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D 4 receptor gene. Alleles that were less than four repeats long and four or more ...
作者:Daisuke Nishizawa , Shin Narita ...
来源:[J].Clinical Neuropharmacology(IF 1.815), 2014, Vol.37 (4), pp.108-110Wolters Kluwer
摘要:ABSTRACT: The GSK-3β gene, GSK3B, codes for an enzyme that is a target for the action of mood stabilizers, lithium and possibly valproic acid.In this study, the relationship between haplotypes consisting of single nucleotide polymorphisms (SNPs) of GSK3B −50T/C and −172...
作者:Daisuke Nishizawa , Makoto Nagashima ...
来源:[J].Anesthesia & Analgesia(IF 3.3), 2019, Vol.128 (3), pp.563-568Wolters Kluwer
摘要:BACKGROUND:: Pro- and anti-inflammatory cytokines (adipokines) associated with adipose tissue can modulate inflammatory processes and lead to systemic inflammatory conditions such as metabolic syndrome. In the present pilot study, we investigated 3 major adipokines (leptin, ...

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