全部文献期刊会议图书|学者科研项目
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作者:Daisuke Nishizawa , Junko Hasegawa ...
来源:[J].Cancer Chemotherapy and Pharmacology(IF 2.795), 2017, Vol.79 (6), pp.1179-1186
摘要:Whether age and inter-individual variability of pharmacogenetics are risk factors for paclitaxel-induced peripheral neuropathy (PIPN) is inconclusive. This study was conducted to evaluate the influence of previously investigated single nucleotide polymorphisms (SNPs) and age, usi...
作者:Daisuke Nishizawa , Shinya Kasai ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2018, Vol.136 (3), pp.107-113
摘要:Abstract(#br)Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain an...
作者:Daisuke Nishizawa , Makoto Nagashima ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (9)
摘要:Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK) chan...
作者:Daisuke Nishizawa , Ken-ichi Fukuda ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (8)
摘要:Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, lead to different proper doses of fentanyl, which can hamper effective pain treatment. Voltage-activated Ca(2+) channels (VACCs) play a crucial role in the nervous system by controlling membran...
作者:Daisuke Nishizawa , Kazutaka Ikeda ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (10)
摘要:The single nucleotide polymorphism (SNP) rs13438494 in intron 24 of PCLO was significantly associated with bipolar disorder in a meta-analysis of genome-wide association studies. In this study, we performed functional minigene analysis and bioinformatics prediction of splicing re...
作者:Daisuke Nishizawa , Shinya Kasai ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2019, Vol.121 (1), pp.48-57
摘要:Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, ...
作者:Daisuke Nishizawa , Tsutomu Mieda ...
来源:[J].Journal of Pain(IF 3.24), 2016, Vol.17 (10), pp.1126-1134
摘要:Abstract(#br)Ca v 2.3 (R-type) voltage-activated Ca 2+ channels (VACCs), encoded by the calcium channel, voltage-dependent, R-type, α1E subunit ( CACNA1E ) gene, are responsible for transmission of somatic inflammatory pain, and activation of antinociception elicited by visc...
作者:Daisuke Nishizawa , Junko Hasegawa ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2015, Vol.127 (3), pp.391-393
摘要:Abstract(#br)An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 ( TRPC3 ) gene was suggested by our previous gen...
作者:Daisuke Nishizawa , Yasukazu Ogai ...
来源:[J].Neuroscience Letters(IF 2.026), 2010, Vol.479 (1), pp.40-43
摘要:Abstract(#br)Although the serotonin (5-hydroxytryptamine (5-HT)) 2A receptor has been reported to be associated with pain, no relationship has been found between single nucleotide polymorphisms in the 5-HT2A receptor gene and analgesic requirements. To clarify the mechanism of in...
作者:Daisuke Nishizawa , Shinya Kasai ...
来源:[J].Neuroscience Letters(IF 2.026), 2013, Vol.542, pp.1-4
摘要:Abstract(#br)To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D 4 receptor gene. Alleles that were less than four repeats long and four or more ...

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