全部文献期刊会议图书|学者科研项目
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作者:Cristiano Bolchi , Francesco Bavo ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2017, Vol.125, pp.1132-1144
摘要:Abstract(#br)Each of the four aromatic –CH= of ( S,R )-2-pyrrolidinyl-1,4-benzodioxane [( S,R )- 6 ] and of its epimer at the dioxane stereocenter ( S,S )- 6 , previously reported as α4β2 nAChR ligands, was replaced with nitrogen. The resulting four diastereoisomeric pairs o...
作者:Cristiano Bolchi , Francesco Bavo ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (23), pp.5613-5617
摘要:Abstract(#br)A series of 3-nitrophenyl and 3-hydroxyphenyl ethers of ( S )- N -methylprolinol bearing bulky and lipophilic substituents at phenyl C5 were tested for affinity at α4β2 and α3β4 nAChRs. The two phenyl ethers 5-substituted with 6-hydroxy-1-hexynyl showed hig...
作者:Cristiano Bolchi , Laura Fumagalli ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.89, pp.252-265
摘要:Abstract(#br)A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC...
作者:Cristiano Bolchi , Laura Fumagalli ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2016, Vol.120, pp.227-243
摘要:Abstract(#br)Lipophilic substituents at benzodioxane C (7) of 3-(benzodioxan-2-ylmethoxy)-2,6-difluorobenzamide improve the antibacterial activity against methicillin-resistant Staphylococcus aureus strains to MIC values in the range of 0.2–2.5 μg/mL, whereas hydrophilic sub...
作者:Cristiano Bolchi , Francesco Bavo
来源:[J].Tetrahedron Letters(IF 2.397), 2016, Vol.57 (18), pp.2009-2011
摘要:Abstract(#br)Unlike the diastereomeric 1-phenylethylammonium salts, the diastereomeric N -1-phenylethylamides of ( S )- and ( R )-1,4-benzodioxane-2-carboxylic acid show significant differences in fusibility and solubility so as to be efficiently resolved by precipitation of the ...
作者:Cristiano Bolchi , Marco Pallavicini ...
来源:[J].Pharmacological Research(IF 4.346), 2016, Vol.103, pp.215-226
摘要:Abstract(#br)The progression of prostate cancer (PC) to a metastatic hormone refractory disease is the major contributor to the overall cancer mortality in men, mainly because the conventional therapies are generally ineffective at this stage. Thus, other therapeutic options...
作者:Cristiano Bolchi , Marco Pallavicini ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2011, Vol.21 (18), pp.5408-5412
摘要:Abstract(#br)Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed replacing internal dipeptide AA with 4-amino-2-phenylbenzoic acid and cysteine ( C ) with 2-amino-4-thiazolyl-, 2-mercapto-4-thiazolyl-, 2-mercapto-4-imidazolyl- and 2-methylmercapto-4-thiazoly...
作者:Cristiano Bolchi , Marco Pallavicini ...
来源:[J].Tetrahedron: Asymmetry(IF 2.115), 2012, Vol.23 (3-4), pp.217-220
摘要:Abstract(#br)Carnitinamide chloride, an immediate synthetic precursor of carnitine, was chlorinated at the amide nitrogen. The resultant carnitinechloramide chloride, when treated with a base, revealed that the first-formed isolable and characterisable carnitinechloramide in...
作者:Cristiano Bolchi , Marco Pallavicini ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2007, Vol.17 (22), pp.6192-6196
摘要:Abstract(#br)2- o -Tolyl or 2- o -anisyl substituted 4-hydroxy- and 4-carboxybenzamides of methionine, etherified and amidified with 2-hydroxymethyl- and 2-aminomethylpyridodioxane, respectively, are described as inhibitors of Ras protein farnesyltransferase (FTase). Of the sixte...

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