全部文献期刊会议图书|学者科研项目
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作者:... France James , Crean StJohn , Singhrao Sim K
来源:[J].Frontiers in aging neuroscience(IF 5.224), 2017, Vol.9, pp.408
摘要:Periodontal disease is of established etiology in which polymicrobial synergistic ecology has become dysbiotic under the influence of Porphyromonas gingivalis . Following breakdown of the host's protective oral tissue barriers, P. gingivalis migrates to developing inflammatory pa...
作者:Crean StJohn , Olsen Ingar
来源:[J].Frontiers in aging neuroscience(IF 5.224), 2017, Vol.9, pp.336
摘要:As far back as the eighteenth and early nineteenth centuries, microbial infections were responsible for vast numbers of deaths. The trend reversed with the introduction of antibiotics coinciding with longer life. Increased life expectancy however, accompanied the emergence o...
作者:... Robinson Sarita J , Crean StJohn , Singhrao Sim K
来源:[J].Frontiers in aging neuroscience(IF 5.224), 2017, Vol.9, pp.398
摘要:Longitudinal monitoring of patients suggests a causal link between chronic periodontitis and the development of Alzheimer's disease (AD). However, the explanation of how periodontitis can lead to dementia remains unclear. A working hypothesis links extrinsic inflammation as a sec...
作者:... Poole Sophie , Kesavalu Lakshmyya , Crean StJohn
来源:[J].Mediators of inflammation, 2015, Vol.2015, pp.137357
摘要:Periodontal disease (PD) and Alzheimer's disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and alveolar bone resorption ...
作者:Foey Andrew D , Crean Stjohn
来源:[J].PloS one(IF 3.73), 2013, Vol.8 (7), pp.e67955
摘要:Macrophages (MΦs) determine oral mucosal responses; mediating tolerance to commensal microbes and food whilst maintaining the capacity to activate immune defences to pathogens. MΦ responses are determined by both differentiation and activation stimuli, giving rise to two dis...
作者:... Robinson Sarita , Crean StJohn , Singhrao Sim K
来源:[J].Journal of Alzheimer's disease : JAD, 2017, Vol.58 (2), pp.337-348
摘要:A risk factor relationship exists between periodontal disease and Alzheimer's disease (AD) via tooth loss, and improved memory following dental intervention. This links the microbial contribution from indigenous oral periodontal pathogens to the manifestation of chronic cond...
作者:Crean StJohn , Kesavalu Lakshmyya
来源:[J].Journal of Alzheimer's disease : JAD, 2017, Vol.60 (2), pp.359-369
摘要:The polymicrobial dysbiotic subgingival biofilm microbes associated with periodontal disease appear to contribute to developing pathologies in distal body sites, including the brain. This study examined oxidative stress, in the form of increased protein carbonylation and oxi...
作者:Crean Stjohn , Smith Craig ...
来源:[J].Gerodontology, 2017, Vol.34 (3), pp.343-356
摘要:OBJECTIVE(#br)To describe the bacterial profile of the oral flora during the first 2 weeks following a stroke, examining changes in the condition of the oral cavity and infections.(#br)BACKGROUND(#br)Dysphagia is common after a stroke and can lead to aspiration pneumonia. Oral fl...
作者:... Morton L H Glyn , Pearce Mark , Crean StJohn
来源:[J].Current microbiology, 2015, Vol.71 (4), pp.434-42
摘要:Vermamoeba vermiformis is associated with the biofilm ecology of dental-unit waterlines (DUWLs). This study investigated whether V. vermiformis is able to act as a vector for potentially pathogenic bacteria and so aid their dispersal within DUWL systems. Clinical dental wate...
作者:... Velsko Irina , Kesavalu Lakshmyya , Crean StJohn
来源:[J].Journal of Alzheimer's disease : JAD, 2015, Vol.43 (1), pp.67-80
摘要:Periodontal disease is a polymicrobial inflammatory disease that leads to chronic systemic inflammation and direct infiltration of bacteria/bacterial components, which may contribute to the development of Alzheimer's disease. ApoE-/- mice were orally infected (n = 12) with Porphy...

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