全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Clotilde Lecrux , Agne Tubeleviciute-Aydin ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most Caspase-6 inhibitors ha...
作者:Clotilde Lecrux , Hans Imboden
来源:[J].Neurobiology of Disease(IF 5.624), 2014, Vol.68, pp.126-136Elsevier
摘要:Abstract(#br)Angiotensin II (AngII) receptor blockers that bind selectively AngII type 1 (AT1) receptors may protect from Alzheimer’s disease (AD). We studied the ability of the AT1 receptor antagonist losartan to cure or prevent AD hallmarks in aged (~ 18 months at endpoint...
作者:Clotilde Lecrux , Tahar Aboulkassim ...
来源:[J].The American Journal of Pathology(IF 4.522), 2010, Vol.177 (6), pp.3071-3080Elsevier
摘要:High brain levels of amyloid-β (Aβ) and transforming growth factor-β1 (TGF-β1) have been implicated in the cognitive and cerebrovascular alterations of Alzheimer's disease (AD). We sought to investigate the impact of combined increases in Aβ and TGF-β1 on cerebrovascula...
作者:Clotilde Lecrux , David Chatenet ...
来源:[J].Experimental Neurology(IF 4.645), 2007, Vol.210 (2), pp.577-584Elsevier
摘要:Abstract(#br)Urotensin-II (U-II) is a cyclic peptide identified recently in many mammalian species including man. U-II and its receptor are expressed in the central nervous system, in the cardiovascular system and in other peripheral tissues. Although this peptide has been report...
作者:Clotilde Lecrux , Ara Kocharyan ...
来源:[J].Journal of Cerebral Blood Flow & Metabolism(IF 5.398), 2012, Vol.32 (5), pp.896-906Sage国际出版集团
摘要:Activation of the basal forebrain (BF), the primary source of acetylcholine (ACh) in the cortex, broadly increases cortical cerebral blood flow (CBF), a response downstream to ACh release. Although endothelial nitric oxide and cholinoceptive GABA (γ-aminobutyric acid) intern...
作者:Clotilde Lecrux , Christopher McCabe ...
来源:[J].Stroke(IF 6.158), 2008, Vol.39 (2), pp.448-454Wolters Kluwer
摘要:BACKGROUND AND PURPOSE—: The study aim was to assess the effects of magnesium sulfate (MgSO4) administration on white matter damage in vivo in spontaneously hypertensive rats. METHODS—: The left internal capsule was lesioned by a local injection of endothelin-1 (ET-1; 200 pm...

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