全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Claudie Namane , Eykmar Fett ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (1), pp.25-32
摘要:Abstract(#br)Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.
作者:Claudie Namane , Jérôme Meneyrol ...
来源:[J].Tetrahedron: Asymmetry(IF 2.115), 2001, Vol.12 (15), pp.2185-2189
摘要:Abstract(#br)The preparation of novel optically active benzylic amines by the enantioselective reduction of phenone oximes using chiral oxazaborolidine is described. The choice of the chiral 1,2-amino alcohol ( S )-diphenylvalinol as chiral inducer and that of the benzyl group fo...
作者:Claudie Namane , Patrick Mougenot ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2013, Vol.23 (8), pp.2414-2421
摘要:Abstract(#br)Starting from 11β-HSD1 inhibitors that were active ex vivo but with Cyp 3A4 liability, we obtained a new series of adamantane ureas displaying potent inhibition of both human and rodent 11β-HSD1 enzymes, devoid of Cyp 3A4 interactions, and rationally designed to...
作者:Claudie Namane , Markus Kohlmann ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2013, Vol.23 (6), pp.1817-1822
摘要:Abstract(#br)The discovery of potent benzimidazole stearoyl-CoA desaturase (SCD1) inhibitors by ligand-based virtual screening is described. ROCS 3D-searching gave a favorable chemical motif that was subsequently optimized to arrive at a chemical series of potent and promising SC...
作者:Claudie Namane , Patrick Mougenot ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2011, Vol.21 (8), pp.2244-2251
摘要:Abstract(#br)A High Throughput Screening campaign allowed the identification of a novel class of ureas as 11β-HSD1 inhibitors. Rational chemical optimization provided potent and selective inhibitors of both human and murine 11β-HSD1 with an appropriate ADME profile and ex vi...
作者:Claudie Namane , Eykmar Fett ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2012, Vol.22 (7), pp.2497-2502
摘要:Abstract(#br)A novel class of DGAT1 inhibitors containing a thiadiazole core has been discovered. Chemical optimization lead to inhibitors of human DGAT1 with an appropriate ADME profile and that show in vivo activity in target tissues.

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×