全部文献期刊会议图书|学者科研项目
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作者:Clarke Taylor , Sean T. Murphy ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2012, Vol.22 (7), pp.2536-2543Elsevier
摘要:Abstract(#br)Lipid A is an essential component of the Gram negative outer membrane, which protects the bacterium from attack of many antibiotics. The Lipid A biosynthesis pathway is essential for Gram negative bacterial growth and is unique to these bacteria. The first committed ...
作者:Clarke Taylor , Tong Zhu ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2007, Vol.17 (8), pp.2150-2155Elsevier
摘要:Abstract(#br)Several novel series of nitrile-containing fluoroquinolones with weakly basic amines are reported which have reduced potential for hERG (human ether-a-go-go gene) channel inhibition as measured by the dofetilide assay. The new fluoroquinolones are potent against both...
作者:Clarke Taylor , Dirksen Bussiere ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2006, Vol.16 (8), pp.2247-2251Elsevier
摘要:Abstract(#br)Herein are described a series of novel heterocyclic analogs of the 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one scaffold. These compounds are potent inhibitors of receptor tyrosine kinases and exhibit favorable pharmacokinetic profiles. The synthesis and SAR of the...
作者:Clarke Taylor , Susan Kaufman ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2010, Vol.20 (23), pp.6895-6898Elsevier
摘要:Abstract(#br)PI3 Kinases are a family of lipid kinases mediating numerous cell processes such as proliferation, migration, and differentiation. The PI3 kinase pathway is often de-regulated in cancer through PI3Kα overexpression, gene amplification, mutations, and PTEN phosph...
作者:... Paul A. Renhowe , Cynthia M. Shafer , Clarke Taylor
来源:[J].Tetrahedron Letters(IF 2.397), 2005, Vol.47 (5), pp.657-660Elsevier
摘要:Abstract(#br)We herein describe the discovery of a mild, one-pot tandem acylation–cyclization for the synthesis of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones from 2-aminobenzenecarbonitriles and ethyl 2-benzimidazol-2-yl acetates.
作者:... Yvonne D. Smith , Joseph S. Warmus , Clarke Taylor
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2008, Vol.19 (3), pp.665-669Elsevier
摘要:Abstract(#br)A series of benzyl phenyl ethers (BPEs) is described that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase. The synthesis, SAR, and select ADMET data are provided.
作者:Clarke Taylor , Chad Van Huis ...
来源:[J].OncoImmunology, 2016, Vol.5 (12)Taylor & Francis
摘要:ABSTRACT(#br)RORγt is the key transcription factor controlling the development and function of CD4+ Th17 and CD8+ Tc17 cells. Across a range of human tumors, about 15% of the CD4+ T cell fraction in tumor-infiltrating lymphocytes are RORγ+ ce...

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