全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Claire Jacques , Xavier Houard ...
来源:[J].Joint Bone Spine(IF 2.748), 2012, Vol.79 (6), pp.604-609Elsevier
摘要:Abstract(#br)Purpose(#br)IL-8 and its murine equivalent keratinocyte chemoattractant (Kc), chemokines produced by chondrocytes, contribute to the pathophysiology of osteoarthritis. However, the mechanisms leading to their production are poorly known. We aimed to investigate ...
作者:... Colette Salvat , Francis Berenbaum , Claire Jacques
来源:[J].Arthritis & Rheumatism(IF 7.477), 2013, Vol.65 (7), pp.1831-1842Wiley
摘要:Objective(#br)Mechanical stress plays an important role in cartilage degradation and subchondral bone remodeling in osteoarthritis (OA). The remodeling of the subchondral bone could initiate cartilage loss in OA through the interplay of bone and cartilage. The aim of this st...
作者:... Thomas Pap , Claire Jacques , Francis Berenbaum
来源:[J].Arthritis & Rheumatism(IF 7.477), 2012, Vol.64 (12), pp.3972-3981Wiley
摘要:Abstract(#br)Objective(#br)The main feature of osteoarthritis (OA) is degradation and loss of articular cartilage. Interleukin‐1β (IL‐1β) is thought to have a prominent role in shifting the metabolic balance toward degradation. IL‐1β is first synthesized as an inactive ...
作者:Claire Jacques , Marjolaine Gosset ...
来源:[J].Vitamins and Hormones(IF 2.296), 2006, Vol.74, pp.371-403Elsevier
摘要:Interleukin (IL)‐1 is a cytokine that plays a major role in inflammatory responses in the context of infections and immune‐mediated diseases. IL‐1 refers to two different cytokines, termed IL‐1α and IL‐1β, produced from two genes. IL‐1α and IL‐1β are produced ...
作者:Claire Jacques , Colette Salvat ...
来源:[J].FEBS Letters(IF 3.582), 2002, Vol.518 (1), pp.67-71Elsevier
摘要:Abstract(#br)We have designed a chimeric promoter that can be stimulated by various pro-inflammatory mediators and so drive the expression of therapeutic genes under inflammatory conditions. The promoter has two parts, the [−247/+20] fragment of the human type IIA secreted p...
作者:Claire Jacques , Ginette Thomas ...
来源:[J].Experimental Cell Research(IF 3.557), 1996, Vol.222 (2), pp.379-384Elsevier
摘要:Abstract(#br)This study investigates the ways in which two proinflammatory cytokines, tumor necrosis factor α (TNF) and interleukin-1β (IL1), cause increased production of prostaglandin E 2 (PGE 2 ) in rabbit articular chondrocytes (RAC). Rabbit articular chondrocytes in pri...

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