全部文献期刊会议图书|学者科研项目
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作者:Cinzia Volonté , Susanna Amadio ...
来源:[J].Seminars in Cell and Developmental Biology(IF 6.202), 2019, Vol.94, pp.121-128
摘要:Abstract(#br)Today neuroscience is dominated by the perspective that microglia are essential elements in any integrated view of the nervous system. A number of different neuroinflammatory conditions affect the CNS where microglia involvement, and particularly microgliosis, is not...
作者:Cinzia Volonté , Savina Apolloni , Mario Sabatelli
来源:[J].Pharmacology and Therapeutics(IF 7.793), 2019, Vol.202, pp.120-131
摘要:Abstract(#br)ALS currently remains a challenge despite many efforts in performing successful clinical trials and formulating therapeutic solutions. By learning from current failures and striving for success, scientists and clinicians are checking every possibility to search for m...
作者:Cinzia Volonté , Savina Apolloni ...
来源:[J].Neuropharmacology(IF 4.114), 2016, Vol.104, pp.180-193
摘要:Abstract(#br)By signalling through purinergic receptors classified as ionotropic P2X (for ATP) and metabotropic P1 (for adenosine) and P2Y (mainly for ADP, UDP, UTP, ATP), the extracellular nucleotides and their metabolic derivatives originated by extracellular activity of s...
作者:... Savina Apolloni , Cinzia Volonté , Cinzia Volonté
来源:[J].Frontiers in Cellular Neuroscience(IF 4.469), 2017, Vol.11
摘要:Autophagy and inflammation play determinant roles in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS), an adult-onset neurodegenerative disease characterized by deterioration and final loss of upper and lower motor neurons (MN) priming microglia to sustain neuroinflammatio...
作者:Cinzia Volonté , Carlos Matute
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (4)
摘要:We have developed a rat brain organotypic culture model, in which tissue slices contain cortex-subventricular zone-striatum regions, to model neuroblast activity in response to in vitro ischemia. Neuroblast activation has been described in terms of two main parameters, proliferat...
作者:... Luca Battistini , Cinzia Volonté , Cinzia Volonté
来源:[J].Frontiers in Immunology, 2017, Vol.8
摘要:Multiple sclerosis (MS) is characterized by macrophage accumulation and inflammatory infiltrates into the CNS contributing to demyelination. Because purinergic P2X7 receptor (P2X7R) is known to be abundantly expressed on cells of the hematopoietic lineage and of the nervous ...
作者:... Sebastiano Cavallaro , Cinzia Volonté , Cinzia Volonté
来源:[J].Frontiers in Immunology, 2017, Vol.8
摘要:Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease where activated glia release pro-inflammatory cytokines that trigger a vicious cycle of neurodegeneration in the absence of resolution of inflammation. Given the well-established role of histamine as a ...
作者:Cinzia Volonté , Savina Apolloni ...
来源:[J].Pharmacology and Therapeutics(IF 7.793), 2011, Vol.132 (1), pp.111-122
摘要:Abstract(#br)Amyotrophic lateral sclerosis (ALS) is one of the most common neuromuscular diseases. It is devastating and fatal, causing progressive paralysis of all voluntary muscles and eventually death, while sparing cognitive functions. A pathological hallmark of ALS is neuroi...
作者:Cinzia Volonté , Susanna Amadio ...
来源:[J].Pharmacology and Therapeutics(IF 7.793), 2005, Vol.112 (1), pp.264-280
摘要:Abstract(#br)The present review offers a new perspective on a family of receptors, termed P2 receptors, specific for nucleoside tri- and diphosphates of purines/pyrimidines. We emphasize here that while decoding the inputs of various related extracellular ligands, P2 recepto...
作者:Cinzia Volonté , Nadia D’Ambrosi , Susanna Amadio
来源:[J].Progress in Neurobiology(IF 9.035), 2008, Vol.86 (2), pp.61-71
摘要:Abstract(#br)A constant pattern through the development of cellular life is that not only cells but also subcellular components such as proteins, either being enzymes, receptors, signaling or structural proteins, strictly cooperate. Discerning how protein cooperation originated a...

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