全部文献期刊会议图书|学者科研项目
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作者:Heidi N. Hilton , Christine L. Clarke , J. Dinny Graham
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2018, Vol.466, pp.2-14
摘要:Abstract(#br)The ovarian hormones estrogen and progesterone are master regulators of the development and function of a broad spectrum of human tissues, including the breast, reproductive and cardiovascular systems, brain and bone. Acting through the nuclear estrogen (ER) and prog...
作者:Christine L. Clarke , Erard M. Gilles ...
来源:[J].Gynecologic Oncology(IF 3.929), 2015, Vol.138 (3), pp.663-667
摘要:Abstract(#br)Objective(#br)Hormonal therapy is generally reserved for patients with endometrial cancers that fail cytotoxic chemotherapy, but there is a lack of sufficiently sensitive diagnostics to identify potential responders. We sought to develop a diagnostic technique t...
作者:Christine L. Clarke , Margriet Collée ...
来源:[J].Nature Genetics(IF 35.209), 2018, Vol.50 (7), pp.968-978
摘要:Abstract(#br)The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal gene...
作者:... Peter J. Fuller , George E.O. Muscat , Christine L. Clarke
来源:[J].Molecular Oncology(IF 6.701), 2014, Vol.8 (5), pp.998-1013
摘要:Abstract(#br)Although molecular signatures based on transcript expression in breast cancer samples have provided new insights into breast cancer classification and prognosis, there are acknowledged limitations in current signatures. To provide rational, pathway-based signatu...
作者:... Jane S. Milliken , A. Michael Bilous , Christine L. Clarke
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1996, Vol.56 (1), pp.93-98
摘要:Abstract(#br)The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor which mediates progesterone action in target tissues. Two PR proteins, PR A (81–83 kDa) and PR B (116–120 kDa), have been described and different physiological activities asc...
作者:Christine L. Clarke , Karen Byth ...
来源:[J].Gynecologic Oncology(IF 3.929), 2004, Vol.97 (1), pp.16-25
摘要:Abstract(#br)Objective(#br)BRCA1 mutations predispose to cancer in hormone responsive tissues. A predominance of estrogen receptor (ER)-negative breast cancers in BRCA1 mutation carriers and potential interactions between ERα and BRCA1 suggest a link between hormones and BRC...
作者:Christine L. Clarke , Stephen N. Birrell ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2007, Vol.110 (3), pp.236-243
摘要:Abstract(#br)Androgen signaling, mediated by the androgen receptor (AR), is a critical factor influencing growth of normal and malignant breast cells. Given the increasing use of exogenous androgens in women, a better understanding of androgen action in the breast is essenti...
作者:Matloob Khushi , Christine L. Clarke , J. Dinny Graham
来源:[J].PeerJ, 2014, Vol.2
摘要:Chromatin factors interact with each other in a cell and sequence-specific manner in order to regulate transcription and a wealth of publically available datasets exists describing the genomic locations of these interactions. Our recently published BiSA (Binding Sites Analys...
作者:... Dinny Graham , Christine L. Clarke , Rosemary L. Balleine
来源:[J].Clinical & Experimental Metastasis(IF 3.46), 2018, Vol.35 (1-2), pp.3-13
摘要:Abstract(#br)Ductal carcinoma in situ (DCIS), invasive breast cancer (IBC) and lympho-vascular invasion (LVI) represent distinct stages in breast cancer progression with different clinical implications. Altered microRNA (miRNA) expression may play a role in mediating the pro...

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