全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Christine Coulon , Solène Marie ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2020, Vol.84-85, pp.20-27
摘要:Abstract(#br)Introduction(#br)Glyburide is an approved anti-diabetes drug binding to the sulfonylurea receptors-1 (SUR-1) and substrate of solute carrier (SLC) transporters, which can be isotopically radiolabelled with carbon-11 for PET imaging. The aim of this work is to pr...
作者:Christine Coulon , Françoise Hinnen ...
来源:[J].Life Sciences(IF 2.555), 1998, Vol.64 (5), pp.PL93-PL97
摘要:Abstract(#br)The biodistribution of the nicotinic acetylcholine receptor (nAChR) radioligand 2-[ 18 F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine ([ 18 F]fluoro-A-85380, half-life of fluorine-18 = 110 min) in selected rat brain areas was assessed in vivo. The radiotracer showed a...
作者:Christine Coulon , Michel Bottlaender
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2012, Vol.39 (3), pp.347-359
摘要:Abstract(#br)Introduction(#br)LBT-999, ( E )- N -(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4'-tolyl)nortropane, has been developed for PET imaging of the dopamine transporter. [ 18 F]LBT-999 PET studies in baboons showed a lower brain uptake than [ 11 C]LBT-999 and a high bon...
作者:Christine Coulon , Michèle Ottaviani ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2000, Vol.27 (3), pp.233-238
摘要:Abstract(#br)The radiolabeled catecholamine analogue (1R,2S)-6-[ 18 F]fluorometaraminol (6-[ 18 F]FMR) is a substrate for the neuronal norepinephrine transporter. It has been used as a positron emission tomography (PET) ligand to map sympathetic nerves in dog heart. 6-[ 18 F...
作者:Christine Coulon , Michelle Ottaviani ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2003, Vol.11 (24), pp.5401-5408
摘要:Abstract(#br)Recently, a new series of potent and highly subtype-selective 1-(heteroarylalkynyl)-4-benzylpiperidine antagonists of the NMDA receptors has been described by Pfizer Laboratories. In this series, 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol...
作者:Christine Coulon , Michèle Ottaviani ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2002, Vol.10 (8), pp.2611-2623
摘要:Abstract(#br)Considerable efforts have been engaged in the design, synthesis and pharmacological characterization of radioligands for imaging the serotonin transporter, based on its implication in several neuropsychiatric diseases, such as depression, anxiety and schizophren...
作者:Christine Coulon , Michele Ottaviani ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2003, Vol.11 (24), pp.5333-5343
摘要:Abstract(#br)In recent years, there has been considerable effort to design and synthesize radiotracers suitable for use in Positron Emission Tomography (PET) imaging of the α4β2 neuronal nicotinic acetylcholine receptor (nAChR) subtype. A new fluoropyridinyl derivative of (−...
作者:Christine Coulon , Michèle Ottaviani ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2006, Vol.14 (11), pp.3848-3858
摘要:Abstract(#br)FPhEP ( 1 , (+/−)-2- exo -(2′-fluoro-3′-phenyl-pyridin-5′-yl)-7-azabicyclo[2.2.1]heptane) belongs to a recently described novel series of 3′-phenyl analogues of epibatidine, which not only possess subnanomolar affinity and high selectivity for brain α4...
作者:Christine Coulon , Michéle Ottaviani ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2001, Vol.9 (3), pp.677-694
摘要:Abstract(#br)Fluorine-18- ( t 1/2 109.8 min) and carbon-11 ( t 1/2 20.4 min)-labeled norepinephrine analogues have been found previously to be useful positron-emission-tomography (PET) radioligands to map adrenergic nerve terminals of the heart. Metaraminol ((1 R ,2 S )-2-am...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×