全部文献期刊会议图书|学者科研项目
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作者:Christian Gachet , Thomas Gudermann ...
来源:[J].Cell(IF 31.957), 2017, Vol.171 (6), pp.1368-1382.e23
摘要:Summary(#br)Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune responses. Despite these versatile tasks in mammalian biology, their skills on a cellular level are deemed limited, mainly consisting in rolling, adhesion, and aggregate fo...
作者:Christian Gachet , Kazuhiro Ikenaka ...
来源:[J].Cell Reports, 2017, Vol.19 (6), pp.1151-1164
摘要:Summary(#br)Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we show that microglia transform astrocytes into a neuroprotective phenotype via downre...
作者:Christian Gachet , Pierre H. Mangin ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2018, Vol.61, pp.21-27
摘要:Abstract(#br)Introduction(#br)Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represe...
作者:Christian Gachet , Alain Van Dorsselaer ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (8)
摘要:The CD1e protein participates in the presentation of lipid antigens in dendritic cells. Its transmembrane precursor is transported to lysosomes where it is cleaved into an active soluble form. In the presence of bafilomycin, which inhibits vacuolar ATPase and consequently the aci...
作者:Christian Gachet , Kazuhiro Ikenaka ...
来源:[J].Cell Reports, 2017, Vol.19 (6), pp.1151-1164
摘要:Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we show that microglia transform astrocytes into a neuroprotective phenotype via downregulation of ...
作者:Christian Gachet , Pierre-François Pradat ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)
摘要:Growing evidence supports a link between fatty acid metabolism and amyotrophic lateral sclerosis (ALS). Here we determined the fatty acid composition of blood lipids to identify markers of disease progression and survival. We enrolled 117 patients from two clinical centers and 48...

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