全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Cheng Yi , Qinjie Wu , Changyang Gong
来源:[J].International Journal of Nanomedicine(IF 3.463), 2017, Vol.2017 (default), pp.1499-1514Dove
摘要:The combination of chemotherapy drugs becomes broader cancer clinical trials. However, the poor water solubility of chemotherapeutic drugs restricts their anti-cancer application. In order to improve anti-tumor efficiency and reduce side-effects of free drugs, we prepared PT...
作者:... Qinjie Wu , Yuquan Wei , Changyang Gong
来源:[J].Biomaterials(IF 7.604), 2016, Vol.111, pp.124-137Elsevier
摘要:Abstract(#br)Gene therapy may be a promising and powerful strategy for cancer treatment, but efficient targeted gene delivery i n vivo has so far remained challenging. Here, we developed a well-tailored and versatile “core-shell” ternary system (RRPHC) of systemic gene deliv...
作者:... Qinjie Wu , Yuquan Wei , Changyang Gong
来源:[J].Biomaterials(IF 7.604), 2014, Vol.35 (12), pp.3903-3917Elsevier
摘要:Abstract(#br)Postsurgical peritoneal adhesions are very common and serious complication after surgery. Biodegradable and injectable hydrogels derived from natural polysaccharides are ideal biomaterials for prevention of postoperative adhesion. In this work, we report a class of i...
作者:Changyang Gong , Xiaoning Zhang ...
来源:[J].Biomaterials(IF 7.604), 2016Elsevier
摘要:Abstract(#br)Due to extensive apoptosis defects and multidrug resistance, there is great interest regarding non-apoptotic programmed cell death (PCD) pathways, such as lysosomal-mediated programmed cell death (LM-PCD), necroptosis and autophagy. Because there is an intricate effe...
作者:... Ahmad Fuad Shamsuddin , Rusliza Basir , Changyang Gong
来源:[J].Journal of Nanomaterials(IF 1.547), 2016, Vol.2016Hindawi
摘要:Poor bioavailability of acyclovir in the treatment of viral infections remains one of the major drug delivery concerns of pharmaceutical manufacturers and researchers. Nanoparticulate systems have been exploited with the aim of improving the current pharmacological limitations of...
作者:Changyang Gong , Senyi Deng ...
来源:[J].Biomaterials(IF 7.604), 2013, Vol.34 (4), pp.1413-1432Elsevier
摘要:Abstract(#br)For developing aqueous formulation and improving anti-tumor activity of curcumin (Cur), we prepared Cur encapsulated MPEG-PCL micelles by solid dispersion method without using any surfactants or toxic organic solvent. Cur micelles could be lyophilized into powder for...
作者:ChangYang Gong , QinJie Wu ...
来源:[J].Biomaterials(IF 7.604), 2013, Vol.34 (27), pp.6377-6387Elsevier
摘要:Abstract(#br)A biodegradable in situ gel-forming controlled drug delivery system composed of curcumin loaded micelles and thermosensitive hydrogel was prepared and applied for cutaneous wound repair. Curcumin is believed to be a potent antioxidant and anti-inflammatory agent...
作者:ChangYang Gong , Shuai Shi ...
来源:[J].Acta Biomaterialia(IF 5.093), 2009, Vol.5 (9), pp.3358-3370Elsevier
摘要:Abstract(#br)In this work, a biodegradable and injectable in situ gel-forming controlled drug delivery system based on thermosensitive poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) (PCEC) hydrogel was studied. The prepared PCEC hydrogel undergoes tempe...
作者:... Yuxin Xie , Ping Li , Changyang Gong
来源:[J].Colloids and Surfaces B: Biointerfaces(IF 3.554), 2015, Vol.126, pp.26-34Elsevier
摘要:Abstract(#br)The increasing emergence of multidrug-resistant (MDR) cells presents a challenge to effective cancer therapy. Curcumin (CUR) has multifunctional anticancer properties, but its clinical use has been limited by poor solubility. We developed biodegradable polymeric mice...
作者:... Lei Liu , Xinyu Li , Changyang Gong
来源:[J].Colloids and Surfaces B: Biointerfaces(IF 3.554), 2014, Vol.122, pp.309-315Elsevier
摘要:Abstract(#br)Tissue desiccation is a common cause of postsurgical peritoneal adhesion, which leads a variety of adverse consequences in clinic. Until now, many approaches have been advocated to prevent postsurgical adhesions, but the therapeutic effects were not very encoura...

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