全部文献期刊会议图书|学者科研项目
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作者:... Comlan De Souza , Cécile Enguehard-Gueiffier , Leslie Boudesocque-Delaye
来源:[J].Journal of Ethnopharmacology(IF 2.755), 2017, Vol.204, pp.26-35
摘要:Abstract(#br)Ethnopharmacoligical relevance(#br)Leaves of Crateva adansonii DC (Capparidaceae), a small bush found in Togo, are widely used in traditional medicine to cure infectious abscesses. Traditional healers of Lomé harvest only budding leaves early in the morning, in ...
作者:... Frank Bruyère , Alain Gueiffier , Cécile Enguehard-Gueiffier
来源:[J].Food Control(IF 2.738), 2018, Vol.86, pp.214-223
摘要:Abstract(#br)A fast quality control protocol based on reference BL-DMAC assay and High-performance thin-layer chromatography (HPTLC)-Densitometry was optimized for routine quality control of cranberry ( Vaccinium macrocarpon ) products. The sample preparation appeared as a key st...
作者:Cécile Enguehard-Gueiffier , Alain Gueiffier
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2017, Vol.25 (24), pp.6695-6706
摘要:Abstract(#br)We report the synthesis of a series of imidazo[1,2- a ]pyridine-based molecules as anthelmintic against the livestock parasite Haemonchus contortus . The molecules were tested by using Larval Paralysis Test (LPT), in order to target ionic channels, as most of th...
作者:Cécile Enguehard-Gueiffier , Alain Gueiffier ...
来源:[J].International Journal for Parasitology(IF 3.637), 2018, Vol.48 (7), pp.561-568
摘要:Abstract(#br)The current therapeutic arsenal for toxoplasmosis is restricted to drugs non-specific to the parasite which cause important side effects. Development of more efficient and specific anti- Toxoplasma compounds is urgently needed. Imidazo[1,2- b ]pyridazines designed to...
作者:Cécile Enguehard-Gueiffier , Cédric Logé ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.105, pp.80-105
摘要:Abstract(#br)Using a structure-based design approach, we have developed a new series of imidazo[1,2- b ]pyridazines, targeting the calcium-dependent protein kinase-1 (CDPK1) from Toxoplasma gondii . Twenty derivatives were thus synthesized. Structure-activity relationships and do...
作者:Cécile Enguehard-Gueiffier , Mohamed Abarbri ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (1), pp.114-120
摘要:Abstract(#br)Screening of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC 50 of 15 μM. Structure–activity relationship studies were conducted with 34 newly s...
作者:... Alain Gueiffier , Isabelle Dimier-Poisson , Cécile Enguehard-Gueiffier
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.89, pp.386-400
摘要:Abstract(#br)An in vitro screening of the anti-apicomplexan activity of 51 compounds, stemming from our chemical library and from chemical synthesis, was performed. As a study model, we used Toxoplasma gondii ( T. gondii ), expressing β-galactosidase for the colorimetric ass...
作者:... Alain Gueiffier , Elhadi M. Ahmed , Cécile Enguehard-Gueiffier
来源:[J].Separation and Purification Technology(IF 2.894), 2015, Vol.156, pp.444-449
摘要:Abstract(#br)Aristolochic acids are biologically active and highly toxic secondary metabolites that recently became an important pharmacological tool for in vivo models of acute kidney disorders. Only aristolochic acid I and a mixture of aristolochic acids I and II are curre...
作者:Cécile Enguehard-Gueiffier , Isabelle Thery ...
来源:[J].Tetrahedron(IF 2.803), 2006, Vol.62 (25), pp.6042-6049
摘要:Abstract(#br)Convenient and efficient methods for the preparation of novel 6-amido and 6-phenylsulfanylimidazo[1,2- a ]pyridine derivatives that utilize copper-catalyzed methodologies are reported. These methods are particularly noteworthy because of their experimental simplicity...
作者:Cécile Enguehard-Gueiffier , Florence Fauvelle ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2004, Vol.24 (2), pp.219-227
摘要:Abstract(#br)Four 2,3-diarylimidazo[1,2- a ]pyridines ( I , 1a–c ) were synthesized as inhibitors of UV-induced apoptosis and showed quite different properties. First, only the pyridinyl derivative I showed protection in molt cells. From the supposed intracellular target, ph...

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