全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Britta M. Jacobsen , Kathryn B. Horwitz
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.18-29
摘要:Abstract(#br)This review discusses mechanisms by which progesterone receptors (PR) regulate transcription. We examine available data in different species and tissues regarding: (1) regulation of PR levels; and (2) expression profiling of progestin-regulated genes by total PR...
作者:Britta M. Jacobsen , Eric A. Boen ...
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 1996, Vol.117 (1), pp.27-39
摘要:Abstract(#br)The mechanisms by which steroid receptors repress gene expression are not well understood. In this report, we show that progesterone receptor (PR), in the presence of progesterone (P) directly represses rat gonadotropin releasing hormone (rGnRH) gene transcripti...
作者:... Bryan C. Bergman , Robert H. Eckel , Britta M. Jacobsen
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.363 (1-2), pp.111-121
摘要:Abstract(#br)Progestins induce lipid accumulation in progesterone receptor (PR)-positive breast cancer cells. We speculated that progestin-induced alterations in lipid biology confer resistance to chemotherapy. To examine the biology of lipid loaded breast cancer cells, we used a...
作者:Britta M. Jacobsen , Keith D. Connaghan ...
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.355 (1), pp.15-24
摘要:Abstract(#br)Progesterone receptors (PRs) mediate response to progestins in the normal breast and breast cancer. To determine if liganded PR regulate microRNAs (miRNAs) as a component of their action, we profiled mature miRNA levels following progestin treatment. Indeed, 28 ...
作者:Britta M. Jacobsen , Susan K. Murphy ...
来源:[J].Gynecologic Oncology(IF 3.929), 2012, Vol.127 (1), pp.241-248
摘要:Abstract(#br)Objectives(#br)Cell lines derived from human ovarian and endometrial cancers, and their immortalized non-malignant counterparts, are critical tools to investigate and characterize molecular mechanisms underlying gynecologic tumorigenesis, and facilitate development o...
作者:Britta M. Jacobsen , Jennifer K. Richer ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2005, Vol.97 (4), pp.328-341
摘要:Abstract(#br)Progesterone (P4) is an essential reproductive steroid hormone required for many aspects of female reproductive physiology. Progestins are compounds that demonstrate progesterone-like activity and are used in oral contraception, hormone therapy, and treatment of some...
作者:Britta M. Jacobsen , Ana C. Guerreiro ...
来源:[J].International Journal of Cancer(IF 6.198), 2019, Vol.145 (7), pp.1874-1888
摘要:Progression to hormone‐independent growth leading to endocrine therapy resistance occurs in a high proportion of patients with estrogen receptor alpha (ERα) and progesterone receptors (PR) positive breast cancer. We and others have previously shown that estrogen‐ and pr...
作者:... Paul Jedlicka , Britta M. Jacobsen , Jennifer K. Richer
来源:[J].Molecular Cancer Therapeutics(IF 5.599), 2015, Vol.14 (3), pp.769-778
摘要:Triple-negative breast cancer (TNBC) has the lowest 5-year survival rate of invasive breast carcinomas, and currently there are no approved targeted therapies for this aggressive form of the disease. The androgen receptor (AR) is expressed in up to one third of TNBC and we f...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×