全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Bieke Broux , Bart Van Wijmeersch ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (10)DOAJ
摘要:BACKGROUND AND OBJECTIVE: The long term effects of fingolimod, an oral treatment for relapsing-remitting (RR) multiple sclerosis (MS), on blood circulating B and T cell subtypes in MS patients are not completely understood. This study describes for the first time the longitudinal...
作者:Bieke Broux , Xuehai Wang ...
来源:[J].Neurobiology of Disease(IF 5.624), 2016, Vol.91, pp.292-306Elsevier
摘要:Abstract(#br)T cells are believed to be key effector cells in multiple sclerosis (MS). In this study, we examined the roles of T cell ephrinB1 (EFNB1) and ephrinB2 (EFNB2) in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and MS. We provide evidence that...
作者:Bieke Broux , Elizabeth Gowing , Alexandre Prat
来源:[J].Seminars in Immunopathology(IF 5.379), 2015, Vol.37 (6), pp.577-590Springer
摘要:Abstract(#br)The brain is the organ with the highest metabolic demand in the body. Therefore, it needs specialized vasculature to provide it with the necessary oxygen and nutrients, while protecting it against pathogens and toxins. The blood-brain barrier (BBB) is very tightly re...
作者:Bieke Broux , Jerome J. A. Hendriks ...
来源:[J].Cell Transplantation(IF 4.422), 2016, Vol.25DOAJ
摘要:The aim of this study is to examine whether the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), can generate dendritic cells (DCs) with a stable tolerogenic phenotype to counteract autoimmune responses in an animal model of multiple sclerosis. We investigat...
作者:Bieke Broux , Silva Markovic-Plese ...
来源:[J].Trends in Molecular Medicine(IF 9.571), 2012, Vol.18 (8), pp.446-453Elsevier
摘要:Aging of the immune system contributes to the increased morbidity and mortality of the elderly population and may occur prematurely in patients with immune disorders. One of the main characteristics of immunosenescence is the expansion of CD4 + CD28 – T cells in the blood. T...
作者:Bieke Broux , Kim Pannemans ...
来源:[J].Journal of Autoimmunity(IF 8.145), 2012, Vol.38 (1), pp.10-19Elsevier
摘要:Abstract(#br)Immunosenescence, or ageing of the immune system, contributes to the increased morbidity and mortality seen in the elderly population. Premature immunosenescence is shown to occur in a subgroup of patients with autoimmune diseases. One of the main characteristic...
作者:Evelien Houben , Niels Hellings , Bieke Broux
来源:[J].Frontiers in Immunology, 2019, Vol.10DOAJ
摘要:For a long time, the central nervous system (CNS) was believed to be an immune privileged organ. In the last decades, it became apparent that the immune system interacts with the CNS not only in pathological, but also in homeostatic situations. It is now clear that immune cells i...

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