全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Matthew G. Clark , Bhupendra P. Doctor , Ashima Saxena
来源:[J].Neurotoxicology and Teratology(IF 3.181), 2012, Vol.34 (3), pp.323-330Elsevier
摘要:Abstract(#br)The effects of a large dose of human serum butyrylcholinesterase (HuBChE) were evaluated in rhesus monkeys using a serial-probe recognition (SPR) task designed to assess attention and short-term memory. Each monkey received an intravenous injection of 150 mg (10...
作者:... Alessandro Guiodotti , Bhupendra P. Doctor , Madhusoodana P. Nambiar
来源:[J].Neurotoxicology(IF 2.652), 2012, Vol.33 (2), pp.169-177Elsevier
摘要:Abstract(#br)The chemical warfare nerve agent, soman irreversibly inhibits acetylcholinesterase (AChE) leading to hypercholinergy and seizures which trigger glutamate toxicity and status epilepticus ultimately resulting in neuropathology and neurobehavioral deficits. The sta...
作者:... Edward M. Jakubowski , Robert J. Mioduszewski , Bhupendra P. Doctor
来源:[J].Chemico-Biological Interactions(IF 2.967), 2015, Vol.238, pp.161-169Elsevier
摘要:Abstract(#br)Serum-derived human butyrylcholinesterase (Hu BChE) is a stoichiometric bioscavenger that is being developed as a potential prophylactic nerve agent countermeasure. Previously, we reported the prophylactic efficacy of Hu BChE in Göttingen minipigs against a whol...
作者:... Kunjan A. Patel , Bhupendra P. Doctor , Ashima Saxena
来源:[J].Chemico-Biological Interactions(IF 2.967), 2013, Vol.203 (1), pp.24-29Elsevier
摘要:Abstract(#br)Human serum butyrylcholinesterase (HuBChE) is currently the most suitable bioscavenger for the prophylaxis of highly toxic organophosphate (OP) nerve agents. A dose of 200 mg of HuBChE is envisioned as a prophylactic treatment that can protect humans from an exp...
作者:... Yonas A. Alamneh , Bhupendra P. Doctor , Madhusoodana P. Nambiar
来源:[J].Toxicology Letters(IF 3.145), 2012, Vol.210 (1), pp.87-94Elsevier
摘要:Abstract(#br)Human paraoxonase 1 (PON1), a 45 kDa arylesterase associated with circulating high density lipoproteins (HDL), has been described as an anti-atherogenic element in cardiovascular disorders. The efficacy of PON1 as a catalytic bioscavenger against OP and CWNA toxicity...
作者:Bhupendra P. Doctor , Madhusoodana P. Nambiar
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2013, Vol.23 (5), pp.1544-1547Elsevier
摘要:Abstract(#br)Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures. The natural alkaloid (−)-huperzine A is a potent in...
作者:... Ashima Saxena , Carolyn Chambers , Bhupendra P. Doctor
来源:[J].Journal of Controlled Release(IF 7.633), 2012, Vol.160 (2), pp.217-224Elsevier
摘要:Abstract(#br)We formulated a new gene delivery system based on targeted liposomes. The efficacy of the delivery system was demonstrated in in vitro and in vivo models. The targeting moiety consists of a high-affinity 7-amino-acid peptide, covalently and evenly conjugated to ...
作者:Bhupendra P. Doctor , Manojkumar Valiyaveettil
来源:[J].Toxicology in Vitro(IF 2.65), 2012, Vol.26 (1), pp.182-188Elsevier
摘要:Abstract(#br)Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. To develop PROL as a catalytic bioscavenger, we...

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