全部文献期刊会议图书|学者科研项目
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作者:... Solène Marie , Nicolas Tournier , Bertrand Kuhnast
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2020, Vol.84-85, pp.20-27
摘要:Abstract(#br)Introduction(#br)Glyburide is an approved anti-diabetes drug binding to the sulfonylurea receptors-1 (SUR-1) and substrate of solute carrier (SLC) transporters, which can be isotopically radiolabelled with carbon-11 for PET imaging. The aim of this work is to pr...
作者:Bertrand Kuhnast , Wadad Saba ...
来源:[J].Drug and Alcohol Dependence(IF 3.141), 2017, Vol.170, pp.43-50
摘要:Abstract(#br)Introduction(#br)A growing area of research suggests that neuroimmunity may impact the pharmacology of opioids. Microglia is a key component of the brain immunity. Preclinical and clinical studies have demonstrated that microglial modulators may improve morphine...
作者:Bertrand Kuhnast , Francisco López-Picón ...
来源:[J].Alzheimer's & Dementia: The Journal of the Alzheimer's Association(IF 14.483), 2019, Vol.15 (8), pp.1081-1103
摘要:Abstract(#br)Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for th...
作者:... Géraldine Pottier , Bertrand Kuhnast , Sébastien Jan
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (3)
摘要:The development of a reliable dose monitoring system in hadron therapy is essential in order to control the treatment plan delivery. Positron Emission Tomography (PET) is the only method used in clinics nowadays for quality assurance. However, the accuracy of this method is ...
作者:Bertrand Kuhnast , Jean-Claude Madelmont ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.92, pp.818-838
摘要:Abstract(#br)Melanin pigment represents an attractive target to address specific treatment to melanoma cells, such as cytotoxic radionuclides. However, less than half of the patients have pigmented metastases. Hence, specific marker is required to stratify this patient popul...
作者:Bertrand Kuhnast , Wadad Saba
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2016, Vol.91, pp.98-104
摘要:Abstract(#br)Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro . Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available ( i.e. marketed) P-gp inhi...
作者:Bertrand Kuhnast , Héric Valette ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2006, Vol.33 (6), pp.785-795
摘要:Abstract(#br)FAUC346 ( N -[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzo[ b ]thiophene-2-carboxamide), an in vitro D 3 -selective ligand, and its normethyl derivative have been synthesized from commercially available 1-(2-substituted-phenyl)piperazines. FAUC346 has been l...
作者:Bertrand Kuhnast , Annelaure Damont ...
来源:[J].Applied Radiation and Isotopes(IF 1.179), 2011, Vol.70 (3), pp.489-497
摘要:Abstract(#br)Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amount...
作者:Bertrand Kuhnast , Nicholas Bernards ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2014, Vol.24 (6), pp.1550-1556
摘要:Abstract(#br)A series of four novel analogues of DPA-714, bearing a fluoroalkynyl side chain (with a length ranging from three to six carbon atoms) in replacement of the fluoroethoxy motif, have been synthetized in six steps from commercially available methyl 4-iodobenzoate....

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