全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Bertrand Kuhnast , Irène Buvat ...
来源:[J].BMC Cancer(IF 3.333), 2015, Vol.15 (1)Springer
摘要:Abstract(#br) Background(#br)Clinical studies implying the sunitinib multi-kinase inhibitor have led to disappointing results for breast cancer care but mostly focused on HER2-negative subtypes. Preclinical researches involving this drug mostly concern Triple Negative Breast Canc...
作者:... Géraldine Pottier , Bertrand Kuhnast , Sébastien Jan
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (3)DOAJ
摘要:The development of a reliable dose monitoring system in hadron therapy is essential in order to control the treatment plan delivery. Positron Emission Tomography (PET) is the only method used in clinics nowadays for quality assurance. However, the accuracy of this method is ...
作者:Bertrand Kuhnast , Wadad Saba ...
来源:[J].Drug and Alcohol Dependence(IF 3.141), 2017, Vol.170, pp.43-50Elsevier
摘要:Abstract(#br)Introduction(#br)A growing area of research suggests that neuroimmunity may impact the pharmacology of opioids. Microglia is a key component of the brain immunity. Preclinical and clinical studies have demonstrated that microglial modulators may improve morphine...
作者:... Héric Valette , Bertrand Kuhnast , Michel Bottlaender
来源:[J].The AAPS Journal(IF 4.386), 2013, Vol.15 (4), pp.1082-1090Springer
摘要:Abstract(#br)Glyburide (glibenclamide, GLB) is a widely prescribed antidiabetic with potential beneficial effects in central nervous system injury and diseases. In vitro studies show that GLB is a substrate of organic anion transporting polypeptide (OATP) and ATP-binding cas...
作者:Bertrand Kuhnast , Jean-Claude Madelmont ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.92, pp.818-838Elsevier
摘要:Abstract(#br)Melanin pigment represents an attractive target to address specific treatment to melanoma cells, such as cytotoxic radionuclides. However, less than half of the patients have pigmented metastases. Hence, specific marker is required to stratify this patient popul...
作者:Bertrand Kuhnast , Wadad Saba
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2016, Vol.91, pp.98-104Elsevier
摘要:Abstract(#br)Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro . Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available ( i.e. marketed) P-gp inhi...
作者:Bertrand Kuhnast , Nicholas Bernards ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2014, Vol.24 (6), pp.1550-1556Elsevier
摘要:Abstract(#br)A series of four novel analogues of DPA-714, bearing a fluoroalkynyl side chain (with a length ranging from three to six carbon atoms) in replacement of the fluoroethoxy motif, have been synthetized in six steps from commercially available methyl 4-iodobenzoate....
作者:Bertrand Kuhnast , Hélène Agostini ...
来源:[J].European Journal of Nuclear Medicine and Molecular Imaging(IF 5.114), 2016, Vol.43 (5), pp.852-859Springer
摘要:Abstract(#br) Purpose(#br)In this prospective study, our goal was to emphasize the diagnostic value of combining 11C-choline and 18F-FDG PET/CT for hepatocellular carcinoma (HCC) in patients with chronic liver disease.(#br) Methods(#br)Thirty-three cons...
作者:Stéphane Le Helleix , Frédéric Dollé , Bertrand Kuhnast
来源:[J].Applied Radiation and Isotopes(IF 1.179), 2013, Vol.82, pp.7-11Elsevier
摘要:Abstract(#br)Carbon-11-labeled acetate ([1- 11 C]acetate) is a radiopharmaceutical of importance in clinical practice as well as in preclinical research in cardiology and oncology. Its preparation is based on the [ 11 C]carboxylation reaction of a Grignard reagent with [ 11 C]CO ...
作者:Bertrand Kuhnast , Frédéric Dollé ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2013, Vol.40 (7), pp.887-895Elsevier
摘要:Abstract(#br)Introduction(#br)[ 18 F]Fallypride, a fluorinated and substituted benzamide with high affinity for D 2 /D 3 receptors, is a useful PET radioligand for the study of striatal/extrastriatal areas. Since [ 18 F]fallypride is extensively metabolized in vivo and since...

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