全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Bernd Meibohm , Weihua Li
来源:[J].Pharmaceutical Research(IF 4.742), 2017, Vol.34 (9), pp.1925-1933Springer
摘要:Although the prevalence of alcohol consumption is higher in HIV+ people than general public, limited information is available on how alcohol affects the metabolism and bioavailability of darunavir (DRV).
作者:Bernd Meibohm , Joshua Galanter ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (6)DOAJ
摘要:BACKGROUND: Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to de...
作者:Bernd Meibohm , Weihua Li
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (2)DOAJ
摘要:Elvitegravir (EVG), an integrase inhibitor for the treatment HIV infection, is increasingly becoming the part of first-line antiretroviral therapy (ART) regimen. EVG is mainly metabolized through cytochrome P450 (CYP) 3A4. Previously, we have shown that ethanol alters ART-CY...
作者:... Narendra Chirmule , Bernd Meibohm , Vibha Jawa
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (2), pp.447-455Springer
摘要:Abstract(#br)In the clinical setting, anti-drug antibodies (ADA) against biotherapeutics can influence patient safety and interfere with product efficacy. High immunogenicity has been addressed in clinic by concomitant immune suppression, such as co-administration of methotrexate...
作者:... Vivian Loveless , Richard E. Lee , Bernd Meibohm
来源:[J].The AAPS Journal(IF 4.386), 2016, Vol.18 (3), pp.788-791Springer
摘要:Abstract(#br)The in vivo biodistribution and pharmacokinetics of 1329, a novel spectinamide antibiotic with anti-tubercular activity, were studied during intravenous administration of an tritium-labeled compound for nine consecutive, 12-hourly doses to rats. Serial blood sam...
作者:Johan Gabrielsson , Bernd Meibohm , Daniel Weiner
来源:[J].The AAPS Journal(IF 4.386), 2016, Vol.18 (1), pp.47-63Springer
摘要:Abstract(#br) Pattern recognition is a key element in pharmacokinetic data analyses when first selecting a model to be regressed to data. We call this process going from data to insight and it is an important aspect of exploratory data analysis (EDA). But there are very few forma...
作者:... Dorababu Madhura , Bernd Meibohm , Monica M. Jablonski
来源:[J].The AAPS Journal(IF 4.386), 2014, Vol.16 (2), pp.311-323Springer
摘要:Abstract(#br)Asialo, tri-antennary oligosaccharide (NA3 glycan) is an endogenous compound, which supports proper folding of outer segment membranes, promotes normal ultrastructure, and maintains protein expression patterns of photoreceptors and Müller cells in the absence of...
作者:... Anthony J. Hickey , Bernd Meibohm , Mercedes Gonzalez-Juarrero
来源:[J].Tuberculosis(IF 3.033), 2019, Vol.117, pp.52-55Elsevier
摘要:Abstract(#br)Pharmacokinetic/pharmacodynamic studies of anti-tuberculosis agents in animal models of tuberculosis are hampered by the frequent necessity to perform sample bioanalysis outside the biosafety level-3 environment. Thus, each specimen has to undergo tedious and time-co...

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