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作者:Bernard Lardy , Françoise Morel
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2020, Vol.521 (2), pp.383-388
摘要:Abstract(#br)The NADPH oxidase Nox4 is a multi-pass membrane protein responsible for the generation of reactive oxygen species that are implicated in cellular signaling but may also cause pathological situations when dysregulated. Although topological organization of integral mem...
作者:... Laurent Grange , Françoise Morel , Bernard Lardy
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (6)
摘要:Interleukin-1β (IL-1β) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). We confirmed that in human C-20/A4 chondrocytes the NAD...
作者:Bernard Lardy , Francis Rousset ...
来源:[J].Biochemical Pharmacology(IF 4.576), 2013, Vol.85 (11), pp.1644-1654
摘要:Abstract(#br)NADPH oxidase Nox4 is expressed in a wide range of tissues and plays a role in cellular signaling by providing reactive oxygen species (ROS) as intracellular messengers. Nox4 oxidase activity is thought to be constitutive and regulated at the transcriptional lev...
作者:... Jean-Luc Lenormand , Bernard Lardy , Françoise Morel
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2012, Vol.419 (3), pp.453-458
摘要:Abstract(#br)The membrane protein NADPH (nicotinamide adenine dinucleotide phosphate) oxidase Nox4 constitutively generates reactive oxygen species differing from other NADPH oxidases activity, particularly in Nox2 which needs a stimulus to be active. Although the precise me...
作者:Bernard Lardy , Algirdas J. Jesaitis ...
来源:[J].Biochimie(IF 3.142), 2011, Vol.93 (3), pp.457-468
摘要:Abstract(#br)Nox4, a member of Nox family of NADPH oxidase expressed in nonphagocytic cells, is a major source of reactive oxygen species in many cell types. But understanding of the role of Nox4 in the production of ROS and of regulation mechanism of oxidase activity is lar...
作者:Bernard Lardy , Minh Vu Chuong Nguyen ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2007, Vol.361 (2), pp.493-498
摘要:Abstract(#br)Oxidative stress is a metabolic situation used by immune cells to provide protection against infection. Under activation by threatening elements, phagocytes produce chemically toxic molecules, namely the reactive oxygen species (ROS) and reactive nitrogen species (RN...
作者:Karen Bedard , Bernard Lardy , Karl-Heinz Krause
来源:[J].Biochimie(IF 3.142), 2007, Vol.89 (9), pp.1107-1112
摘要:Abstract(#br)NOX family NADPH oxidases are enzymes whose biological function is electron transport and the generation of reactive oxygen species (ROS). NOX enzymes in mammalian organisms have received most attention. However, NOX enzymes are widely distributed in different kingdo...
作者:Bernard Lardy , Marie-José Stasia
来源:[J].Biochimie(IF 3.142), 2007, Vol.89 (9), pp.1145-1158
摘要:Abstract(#br)Cytochrome b 558 is the catalytic core of the phagocyte NADPH oxidase that mediates the production of bactericidal reactive oxygen species. Cytochrome b 558 is formed by two subunits gp91-phox and p22-phox (1/1), non-covalently associated. Its activation depends on t...
作者:Bernard Lardy , Laurent Grange
来源:[J].Polymers(IF 1.687), 2014, Vol.6 (7), pp.1948-1957
摘要:In this paper, we propose the evaluation of the mannitol’s ability to reduce hyaluronic acid (HA) degradation using two different models of oxidative stress. Firstly, a solution of hyaluronan and a solution of the same HA including mannitol in PBS buffer were submitted to an...
作者:Bernard Lardy , Mireille Bof ...
来源:[J].BBA - Molecular Cell Research(IF 4.808), 2005, Vol.1744 (2), pp.199-212
摘要:Abstract(#br)Membrane-associated NADPH oxidase complexes catalyse the production of the superoxide anion radical from oxygen and NADPH. In mammalian systems, NADPH oxidases form a family of at least seven isoforms that participate in host defence and signalling pathways. We repor...

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