全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Berislav V. Zlokovic , Peter C. Searson ...
来源:[J].Fluids and Barriers of the CNS, 2017, Vol.14 (1)Springer
摘要:A trans-agency workshop on the blood–brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7–8, 2016. Th...
作者:... José A. Fernández , Patrick D. Lyden , Berislav V. Zlokovic
来源:[J].Thrombosis Research(IF 3.133), 2016, Vol.141, pp.S62-S64Elsevier
摘要:Abstract(#br)Activated protein C (APC) is a plasma serine protease that is capable of antithrombotic, anti-inflammatory, anti-apoptotic, and cell-signaling activities. Animal injury studies show that recombinant APC and some of its mutants are remarkably therapeutic for a wi...
作者:... Robert H. Chow , Berislav V. Zlokovic , Justin K. Ichida
来源:[J].Cell Stem Cell(IF 25.315), 2019, Vol.25 (4), pp.486-500.e9Elsevier
摘要:Summary(#br)Although cellular reprogramming enables the generation of new cell types for disease modeling and regenerative therapies, reprogramming remains a rare cellular event. By examining reprogramming of fibroblasts into motor neurons and multiple other somatic lineages, we ...
作者:... Melanie D. Sweeney , Abhay P. Sagare , Berislav V. Zlokovic
来源:[J].BBA - Molecular Basis of Disease(IF 4.91), 2016, Vol.1862 (5), pp.887-900Elsevier
摘要:Abstract(#br)Vascular insults can initiate a cascade of molecular events leading to neurodegeneration, cognitive impairment, and dementia. Here, we review the cellular and molecular mechanisms in cerebral blood vessels and the pathophysiological events leading to cerebral bl...
作者:... Steven S. Schreiber , Mark Fisher , Berislav V. Zlokovic
来源:[J].Thrombosis Research(IF 3.133), 1998, Vol.92 (5), pp.213-219Elsevier
摘要:Abstract(#br)The anticoagulant transmembrane glycoprotein thrombomodulin (TM) is expressed at the luminal surface of vascular endothelial cells. Recently, we showed that TM antigen and TM mRNA are expressed in brain microvessels in several species and that brain capillaries ...
作者:Berislav V. Zlokovic , Zhen Zhao
来源:[J].Cell Stem Cell(IF 25.315), 2016, Vol.19 (5), pp.663-671Elsevier
摘要:Summary(#br)The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urgent study of the molecular mechanisms underlying ZIKV pathogenesis. Akt-mTOR signaling is one of the key cellular ...
作者:... Helena C. Chui , Meng Law , Berislav V. Zlokovic
来源:[J].Neuron(IF 15.766), 2015, Vol.85 (2), pp.296-302Elsevier
摘要:Summary(#br)The blood-brain barrier (BBB) limits entry of blood-derived products, pathogens, and cells into the brain that is essential for normal neuronal functioning and information processing. Post-mortem tissue analysis indicates BBB damage in Alzheimer’s disease (AD). T...
作者:... Amy R. Nelson , Christer Betsholtz , Berislav V. Zlokovic
来源:[J].Cell(IF 31.957), 2015, Vol.163 (5), pp.1064-1078Elsevier
摘要:Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanis...

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