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作者:Bart O. Roep , Carla J. Greenbaum
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (11), pp.2139-2147
摘要:Type 1 diabetes is an autoimmune disease arising from the destruction of pancreatic insulin-producing beta cells. The disease represents a continuum, progressing sequentially at variable rates through identifiable stages prior to the onset of symptoms, through diagnosis and into ...
作者:... Annet van Royen-Kerkhof , Tatjana Nikolic , Bart O. Roep
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (11), pp.2252-2255
摘要:Type 1 diabetes is believed to be an autoimmune disease associated with irreversible loss of insulin secretory function that follows a chronic progressive course. However, it has been speculated that relapsing/remitting disease progression may occur in type 1 diabetes.
作者:Stef J. Bloem , Bart O. Roep
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (7), pp.1185-1189
摘要:The role of B lymphocytes in the pathogenesis of type 1 diabetes in humans is not entirely evident. These cells are presumed to be important, but this assumption is largely based on animal models of autoimmune diabetes, where compelling evidence for the contribution of both ...
作者:... Eugene P. Brandon , Daniel Pipeleers , Bart O. Roep
来源:[J].Diabetologia(IF 6.487), 2017, Vol.60 (1), pp.126-133
摘要:To overcome the donor shortage in the treatment of advanced type 1 diabetes by islet transplantation, human embryonic stem cells (hESCs) show great potential as an unlimited alternative source of beta cells. hESCs may have immune privileged properties and it is important to deter...
作者:Bart O. Roep
来源:[J].Nature Medicine(IF 22.864), 2019, Vol.25 (12), pp.1816-1818
摘要:Enteroviral infection persistence as determined by host genetic susceptibility, rather than independent, short-lived infections, may contribute to islet autoimmunity and be a precursor to the development of type 1 diabetes.
作者:... Rob C. Hoeben , Bart O. Roep , Arnaud Zaldumbide
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-9
摘要:Abstract During type 1 diabetes development, cells in the islets of Langerhans engage adaptive mechanisms in response to inflammatory signals to cope with stress, to restore cellular homeostasis, and to preserve cell function. Disruption of these mechanisms may induce the fo...
作者:... Bart Keymeulen , Peter In't Veld , Bart O. Roep
来源:[J].Cell Transplantation(IF 4.422), 2017, Vol.26
摘要:Transplantation of islet allografts into type 1 diabetic recipients usually requires multiple pancreas donors to achieve insulin independence. This adds to the challenges of immunological monitoring of islet transplantation currently relying on surrogate immune markers in periphe...
作者:... Tatjana Nikolic , Bart O. Roep , Bart O. Roep
来源:[J].Frontiers in Immunology, 2017, Vol.8
摘要:Tolerogenic dendritic cells (tolDCs) have reached patients with autoimmune and inflammatory disease, at least in clinical trials. The safety of tolDCs as intervention therapy has been established, but the capacity to modulate autoimmune response in vivo remains to be demonst...
作者:Maria J.L. Kracht , Arnaud Zaldumbide , Bart O. Roep
来源:[J].Trends in Endocrinology & Metabolism(IF 8.901), 2016, Vol.27 (6), pp.353-362
摘要:Type 1 diabetes (T1D) is characterized by the selective and progressive destruction of insulin-producing beta cells by the immune system. An incomplete thymic selection against self-reactive islet antigens partly explains how these T cells reach the periphery and become diabetoge...

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