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作者:... Janne Lehtiö , Barbro Ek-Rylander , Göran Andersson
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Tartrate-resistant acid phosphatase (TRAP/ ACP5 ), a metalloenzyme that is characteristic for its expression in activated osteoclasts and in macrophages, has recently gained considerable focus as a driver of metastasis and was associated with clinically relevant parameters of can...
作者:Barbro Ek-Rylander , Michael Krumpel ...
来源:[J].Calcified Tissue International(IF 2.495), 2017, Vol.101 (1), pp.92-101Springer
摘要:Phosphorylated osteopontin (OPN) inhibits hydroxyapatite crystal formation and growth, and bone alkaline phosphatase (BALP) promotes extracellular mineralization via the release of inorganic phosphate from the mineralization inhibitor inorganic pyrophosphate (PPi). Tartrate-...
作者:Barbro Ek-Rylander , Joe W Ramos
来源:[J].PLoS ONE(IF 3.73), 2010, Vol.5 (6)DOAJ
摘要:Changes in cell adhesion and migration in the tumor microenvironment are key in the initiation and progression of metastasis. R-Ras is one of several small GTPases that regulate cell adhesion and migration on the extracellular matrix, however the mechanism has not been completely...
作者:... Per-Georg Nyholm , Barbro Ek-Rylander , Göran Andersson
来源:[J].Experimental Cell Research(IF 3.557), 2015, Vol.339 (1), pp.154-162Elsevier
摘要:Abstract(#br)Tartrate-resistant acid phosphatase (TRAP/ ACP5 /uteroferrin/purple acid phosphatase/PP5) has received considerable attention as a newly discovered proinvasion metastasis driver associated with different malignancies. This renders TRAP an interesting target for ...
作者:Barbro Ek-Rylander , Göran Andersson
来源:[J].Experimental Cell Research(IF 3.557), 2009, Vol.316 (3), pp.443-451Elsevier
摘要:Abstract(#br)Osteopontin (OPN) is a multifunctional protein implicated in cellular adhesion and migration. Phosphorylation has emerged as a post-translational modification important for certain biological activities of OPN. This study demonstrates that adhesion of isolated n...
作者:Barbro Ek-Rylander , Mikael Wendel
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2010, Vol.394 (3), pp.593-599Elsevier
摘要:Abstract(#br)Prothrombin is converted to thrombin by factor Xa in the cell-associated prothrombinase complex. Prothrombin is present in calcified bone matrix and thrombin exerts effects on osteoblasts as well as on bone resorption by osteoclasts.(#br)We investigated whether (1) o...
作者:Serhan Zenger , Barbro Ek-Rylander , Göran Andersson
来源:[J].BBA - Molecular Cell Research(IF 4.808), 2010, Vol.1803 (5), pp.598-607Elsevier
摘要:Abstract(#br)Tartrate-resistant acid phosphatase, although encoded by a single gene, exists as two isoforms in human serum, TRAP 5a and 5b, differing in post-translational modifications such as proteolytic processing and kinetic properties including pH optimum and specific activi...
作者:Barbro Ek-Rylander , Mikael Wendel
来源:[J].Experimental Hematology(IF 2.907), 2010, Vol.39 (3), pp.339-350.e3Elsevier
摘要:Objective(#br)Prothrombin (PT) and osteopontin (OPN) promote adhesion of bone-derived tartrate-resistant acid phosphatase (TRAP, Acp5)–positive multinucleated cells differing in size, morphology, and resorptive activity. Here we explored phenotypic and functional differences...
作者:Barbro Ek-Rylander , Erik Karlström ...
来源:[J].Experimental Cell Research(IF 3.557), 2007, Vol.314 (3), pp.638-650Elsevier
摘要:Abstract(#br)Prothrombin (PT) is an RGD-containing bone-residing precursor to the serine protease thrombin (TH), which acts as an agonist for a variety of cellular responses in osteoblasts and osteoclasts. We show here that PT, TH, osteopontin (OPN) and fibronectin (FN) prom...
作者:... Carina Svensson , Barbro Ek-Rylander , Göran Andersson
来源:[J].Journal of Molecular Biology(IF 3.905), 1999, Vol.290 (1), pp.201-211Elsevier
摘要:Abstract(#br)Tartrate-resistant acid phosphatase (TRAP) is a mammalian di-iron-containing enzyme that belongs to the family of purple acid phosphatases (PAP). It is highly expressed in a limited number of tissues, predominantly in bone-resorbing osteoclasts and in macrophage...

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