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作者:... Patrick T. Flaherty , Barbara S. Beckman , Matthew E. Burow
来源:[J].Cancer Letters(IF 4.258), 2017, Vol.392, pp.51-59
摘要:Abstract(#br)Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK constituents have well-defined roles in oncogenesis, the MEK5 pathway has only recently emerg...
作者:... John L. Clayton , Bernard M. Jaffe , Barbara S. Beckman
来源:[J].Surgery(IF 3.373), 2001, Vol.130 (2), pp.143-150
摘要:Abstract(#br)Background. Nuclear factor-kappa B (NF-κB) is a known survival pathway, and it may explain differential sensitivity to tumor necrosis factor-alpha (TNF-α) and chemotherapeutic-induced apoptosis in apoptotically sensitive (APO+) and apoptotically resistant (APO−)...
作者:... Yong-Yu Liu , Maryam Foroozesh , Barbara S. Beckman
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2014, Vol.22 (4), pp.1412-1420
摘要:Abstract(#br)Multidrug-resistance is a major cause of cancer chemotherapy failure in clinical treatment. Evidence shows that multidrug-resistant cancer cells are as sensitive as corresponding regular cancer cells under the exposure to anticancer ceramide analogs. In this wor...
作者:Barbara S. Beckman , Thomas E. Cleveland ...
来源:[J].Steroids(IF 2.803), 2010, Vol.75 (12), pp.870-878
摘要:Abstract(#br)Glyceollins are pterocarpan phytoalexins elicited in high concentrations when soybeans are stressed. We have previously reported that the three glyceollin isomers (GLY I–III) exhibit antiestrogenic properties, which may have significant biological effects upon h...
作者:James W. Antoon , Barbara S. Beckman
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2012, Vol.22 (7), pp.2624-2628
摘要:Abstract(#br)The ceramide-sphingosine-1-phosphate rheostat is a promising therapeutic target. Here, the novel ceramide analog ( S )-2-(benzylideneamino)-3-hydroxy- N -tetrade-cylpropanamide is shown to block proliferation and enhance the efficacy of the clinical chemotherapeutics...
作者:Barbara S. Beckman , Russell B. Wilson
来源:[J].Biochemical Pharmacology(IF 4.576), 1995, Vol.50 (3), pp.413-419
摘要:Abstract(#br)To investigate the mechanisms that may be involved in zidovudine (AZT)-induced hematopoietic toxicity, spleen cells isolated from phenylhydrazine-treated anemic mice or murine bone marrow erythroid progenitor cells were treated with AZT (1–10 μM) for 24 hr. A co...
作者:... Bernard M. Jaffe , Barbara S. Beckman , Matthew E. Burow
来源:[J].Surgery(IF 3.373), 2002, Vol.132 (2), pp.293-301
摘要:Abstract(#br)Background. Components of the mitogen-activated protein kinase (MAPK) cascade have been implicated in apoptotic regulation. This study used gene expression profiling analysis to identify and implicate mitogen-activated protein kinase kinase (MEK5)-BMK1 (big mito...
作者:... Aline B. Scandurro , Russell B. Wilson , Barbara S. Beckman
来源:[J].FEBS Letters(IF 3.582), 1995, Vol.359 (2), pp.267-270
摘要:Abstract(#br)We have previously identified a cytosolic protein, erythropoietin RNA binding protein (ERBP), which is up-regulated in certain tissues in response to hypoxia. To further characterize the interaction of ERBP and erythropoietin (EPO) mRNA, we have examined the role of ...
作者:... Bridgette M. Collins-Burow , Barbara S. Beckman , John A. McLachlan
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2000, Vol.271 (2), pp.342-345
摘要:Abstract(#br)We found that in MCF-7 breast carcinoma cells, PI3K and Akt suppressed a dose-dependent induction of apoptosis by tumor necrosis factor α (TNF). PI3K and Akt stimulated NF-κB activation in a dose-dependent manner, suggesting a common link between these two pathw...
作者:Barbara A. Drew , Matthew E. Burow , Barbara S. Beckman
来源:[J].BBA - Reviews on Cancer(IF 9.033), 2011, Vol.1825 (1), pp.37-48
摘要:Abstract(#br)While conventional MAP kinase pathways are one of the most highly studied signal transduction molecules, less is known about the MEK5 signaling pathway. This pathway has been shown to play a role in normal cell growth cycles, survival and differentiation. The ME...

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