全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Arne B. Gjuvsland , Kristin Tøndel ...
来源:[J].Computers in Biology and Medicine(IF 1.162), 2014, Vol.53, pp.65-75Elsevier
摘要:Abstract(#br)The mouse is an important model for theoretical–experimental cardiac research, and biophysically based whole organ models of the mouse heart are now within reach. However, the passive material properties of mouse myocardium have not been much studied.(#br)We pre...
作者:Erik Plahte , Arne B. Gjuvsland , Stig W. Omholt
来源:[J].Physica D: Nonlinear Phenomena(IF 1.669), 2013, Vol.256-257, pp.7-20Elsevier
摘要:Abstract(#br)A future quantitative genetics theory should link genetic variation to phenotypic variation in a causally cohesive way based on how genes actually work and interact. We provide a theoretical framework for predicting and understanding the manifestation of genetic...
作者:Arne B. Gjuvsland , Anders Nermoen ...
来源:[J].Journal of The Royal Society Interface(IF 4.907), 2015, Vol.12 (106), pp.20141166-20141166The Royal Society
摘要:A scientific understanding of individual variation is key to personalized medicine, integrating genotypic and phenotypic information via computational physiology. Genetic effects are often context-dependent, differing between genetic backgrounds or physiological states such ...
作者:Arne B. Gjuvsland , Mirte Bosse ...
来源:[J].PLOS Genetics(IF 8.694), 2019, Vol.15 (3)PLOS
摘要:Lethal recessive alleles cause pre- or postnatal death in homozygous affected individuals, reducing fertility. Especially in small size domestic and wild populations, those alleles might be exposed by inbreeding, caused by matings between related parents that inherited the same r...
作者:Arne B. Gjuvsland , Jon Olav Vik ...
来源:[J].The Journal of Physiology(IF 4.38), 2013, Vol.591 (8), pp.2055-2066Wiley
摘要:Abstract The genotype–phenotype map (GP map) concept applies to any time point in the ontogeny of a living system. It is the outcome of very complex dynamics that include environmental effects, and bridging the genotype–phenotype gap is synonymous with understanding these dy...
作者:Arne B. Gjuvsland , Ingrid Måge
来源:[J].Journal of Chemometrics(IF 1.937), 2010, Vol.24 (11鈥?2), pp.738-747Wiley
摘要:Abstract(#br)Computer simulations are faster and cheaper than physical experiments. Still, if the system has many factors to be manipulated, experimental designs may be needed in order to make computer experiments more cost‐effective. Determining the relevant parameter range...
作者:Arne B. Gjuvsland , Elena Garré ...
来源:[J].PLOS Genetics(IF 8.694), 2013, Vol.9 (3)PLOS
摘要:The number of chromosome sets contained within the nucleus of eukaryotic organisms is a fundamental yet evolutionarily poorly characterized genetic variable of life. Here, we mapped the impact of ploidy on the mitotic fitness of baker's yeast and its never domesticated relat...
作者:... Jon Olav Vik , Stig W. Omholt , Arne B. Gjuvsland
来源:[J].PLOS Computational Biology(IF 5.215), 2013, Vol.9 (5)PLOS
摘要:Additive genetic variance ( VA ) and total genetic variance ( VG ) are core concepts in biomedical, evolutionary and production-biology genetics. What determines the large variation in reported VA / VG ratios from line-cross experiments...
作者:Arne B. Gjuvsland , Jon Olav Vik ...
来源:[J].PLOS Computational Biology(IF 5.215), 2012, Vol.8 (4)PLOS
摘要:Polymorphisms identified in genome-wide association studies of human traits rarely explain more than a small proportion of the heritable variation, and improving this situation within the current paradigm appears daunting. Given a well-validated dynamic model of a complex physiol...
作者:Arne B. Gjuvsland , Erik Plahte ...
来源:[J].PLOS ONE(IF 3.73), 2010, Vol.5 (2)PLOS
摘要:Since the dawn of genetics, additive and dominant gene action in diploids have been defined by comparison of heterozygote and homozygote phenotypes. However, these definitions provide little insight into the underlying intralocus allelic functional dependency and thus cannot...

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