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作者:Arlene Gonçalves Corrêa , Tânia Ueda-Nakamura ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2018
摘要:Abstract(#br)Continuous efforts have been made to discover new drugs for the treatment of Chagas’ disease, human African trypanosomiasis, and leishmaniasis. We have previously reported the synthesis and antileishmanial and antitrypanosomal (Y strain) properties of 2,3-disubs...
作者:Arlene Gonçalves Corrêa , Diego Pereira Sangi
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.9 (1)
摘要:Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is considered endemic. The chemotherapy for Chagas disease remains a problem; the standard treatment currently relies on a single drug, benzn...
作者:... Tânia Ueda-Nakamura , Arlene Gonçalves Corrêa , Celso Vataru Nakamura
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.90, pp.107-123
摘要:Abstract(#br)Quinoxalines belong to the N -containing heterocyclic compounds that stand out as having promising biological activity due to their privileged scaffold. In this work, we report the synthesis, antileishmanial, and antitrypanosomal properties of 46 new 2,3-disubst...
作者:Arlene Gonçalves Corrêa , Raquel Petrilli ...
来源:[J].Materials Science & Engineering C(IF 2.404), 2020, Vol.110
摘要:Abstract(#br)The use of nanocarriers for drug delivery is a strategy aimed to improve therapeutic indices through changes in their pharmacokinetic and pharmacodynamic characteristics. Liposomes are well-investigated nanocarriers for drug delivery to macrophage-targeted thera...
作者:Arlene Gonçalves Corrêa , Quezia Bezerra Cass
来源:[J].Journal of Chromatography B(IF 2.487), 2014, Vol.968, pp.87-93
摘要:Abstract(#br)The discovery of selective inhibitors for acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) is extremely important for the development of drugs that can be used in the treatment of patients diagnosed with the Alzheimer's disease (AD). For this reason, ...
作者:Arlene Gonçalves Corrêa , Júlia L. Monteiro ...
来源:[J].Revista Brasileira de Farmacognosia(IF 0.676), 2013, Vol.23 (3), pp.447-454
摘要:Abstract(#br)Two natural amides isolated from the chloroform extract of Piper amalago L., Piperaceae, leaves, a hydrogenated derivative and seven synthetic analogs were tested against the promastigote and intracellular amastigote forms of Leishmania amazonensis . The antilei...
作者:Arlene Gonçalves Corrêa , Quezia Bezerra Cass
来源:[J].Journal of Pharmaceutical and Biomedical Analysis(IF 2.947), 2013, Vol.73, pp.44-52
摘要:Abstract(#br)The aim of the present work is to report on the optimized preparation of capillary enzyme reactors (ICERs) based on acetylcholinesterase (AChE, EC 3.1.1.7), for the screening of selective inhibitors. The AChE-ICERs were prepared by using the homobifunctional lin...
作者:Arlene Gonçalves Corrêa , Thais Marchi Goulart ...
来源:[J].Parasites & Vectors(IF 3.246), 2015, Vol.8 (1)
摘要:Abstract(#br) Background(#br)Similar to other hematophagous insects, male and female sand flies must feed on plants to obtain sugar and, subsequently, energy to complete their life cycles. A large number of compounds emitted by plants may act as volatile signals to these insects....
作者:Arlene Gonçalves Corrêa , Diego Pereira Sangi
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (1)
摘要:Chagas’ disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is considered endemic. The chemotherapy for Chagas disease remains a problem; the standard treatment currently relies on a single drug, ...

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