全部文献期刊会议图书|学者科研项目
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作者:Antonio Cigliano , Frank Dombrowski ...
来源:[J].The American Journal of Pathology(IF 4.522), 2019, Vol.189 (5), pp.1077-1090
摘要:Hepatoblastoma (HB) is the most common type of pediatric liver cancer. Activation of yes-associated protein (YAP) has been implicated in HB molecular pathogenesis. The transcriptional co-activator Yap regulates downstream gene expression through interaction with the TEA doma...
作者:Antonio Cigliano , Silvia Ribback ...
来源:[J].The American Journal of Pathology(IF 4.522), 2018, Vol.188 (4), pp.995-1006
摘要:Primary liver cancer consists mainly of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). A subset of human HCCs expresses a ICC-like gene signature and is classified as ICC-like HCC. The Hippo pathway is a critical regulator of normal and malignant liver ...
作者:Antonio Cigliano , Katja Evert ...
来源:[J].Journal of Hepatology(IF 9.858), 2017
摘要:Background & Aims(#br)Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxal...
作者:Antonio Cigliano , Rebecca Lurie ...
来源:[J].DNA Repair(IF 4.274), 2019, Vol.82
摘要:Abstract(#br)The base excision repair DNA N -glycosylase MBD4 (also known as MED1), an interactor of the DNA mismatch repair protein MLH1, plays a central role in the maintenance of genomic stability of CpG sites by removing thymine and uracil from G:T and G:U mismatches, re...
作者:Antonio Cigliano , Frank Dombrowski ...
来源:[J].Journal of Hepatology(IF 9.858), 2019, Vol.71 (4), pp.742-752
摘要:Background & Aims(#br)The ubiquitin ligase F-box and WD repeat domain-containing 7 (FBXW7) is recognized as a tumor suppressor in many cancer types due to its ability to promote the degradation of numerous oncogenic target proteins. Herein, we aimed to elucidate its role in ...
作者:Antonio Cigliano , Xianqiong Liu ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.12 (9)
摘要:Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene. In the present manuscript, we investigated the effect of Tankyrase inhibitors on the growth of hepatocellular carcinoma...
作者:Antonio Cigliano , Gavinella Latte ...
来源:[J].Journal of Hepatology(IF 9.858), 2016, Vol.64 (2), pp.333-341
摘要:Background & Aims(#br)Cumulating evidence underlines the crucial role of aberrant lipogenesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver.(#br...
作者:Antonio Cigliano , Zixuan Shao ...
来源:[J].Experimental & Molecular Medicine(IF 2.573), 2018, Vol.50 (1), pp.e417-e417
摘要:Abstract(#br)Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase and presents in two distinct complexes: mTORC1 an...
作者:Antonio Cigliano , Silvia Ribback ...
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.69-90
摘要:Abstract(#br)Activation of the AKT/mTOR cascade and overexpression of c-Met have been implicated in the development of human hepatocellular carcinoma (HCC). To elucidate the functional crosstalk between the two pathways, we generated a model characterized by the combined expressi...
作者:Antonio Cigliano , Verena Sailer ...
来源:[J].Journal of Hepatology(IF 9.858), 2013, Vol.58 (6), pp.1147-1156
摘要:Background & Aims(#br)Activation of the AKT/mTOR and Ras/MAPK pathways and the lipogenic phenotype occurs in both a rat model of insulin-induced hepatocarcinogenesis and in human hepatocellular carcinoma (HCC). In the rat model, activation of these pathways is evident within...

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