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作者:... Göran Andersson , Annica Jacobson , Håkan Melhus
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (12)
摘要:An excessive intake of vitamin A has been associated with an increased risk of fractures in humans. In animals, a high vitamin A intake leads to a reduction of long bone diameter and spontaneous fractures. Studies in rodents indicate that the bone thinning is due to increased per...
作者:Annica Jacobson , Alexei Salnikov ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2003, Vol.305 (4), pp.1017-1023
摘要:Abstract(#br)Mechanism(s) for generation of the high tumor interstitial fluid pressure (TIFP) that is characteristic of carcinoma is not known. We investigated the role of hyaluronan, the major water-binding polysaccharide of the extracellular matrix, for the generation of a...
作者:Annica Jacobson , Lijuan Hu ...
来源:[J].Bone(IF 3.823), 2010, Vol.48 (3), pp.496-506
摘要:Abstract(#br)Vitamin A (retinol) is the only molecule known to induce spontaneous fractures in laboratory animals and we have identified retinol as a risk factor for fracture in humans. Since subsequent observational studies in humans and old animal data both show that high retin...
作者:Annica Jacobson , Angela Nebbioso ...
来源:[J].Cancer Cell(IF 24.755), 2009, Vol.16 (3), pp.220-231
摘要:Summary(#br)Growth factor (GF) deprivation and/or blocking of cognate signaling can induce apoptosis and is the basis of several cancer treatment paradigms. We observed that RXR agonists (rexinoids) induce apoptosis of tumor cells when GF support is abrogated. This “rexinoid...
作者:... Göran Andersson , Annica Jacobson , Håkan Melhus
来源:[J].Calcified Tissue International(IF 2.495), 2012, Vol.90 (3), pp.219-229
摘要:Abstract(#br)Vitamin A is the only known compound that produces spontaneous fractures in rats. In an effort to resolve the molecular mechanism behind this effect, we fed young male rats high doses of vitamin A and performed microarray analysis of diaphyseal bone with and without ...
作者:Annica Jacobson , Mehdi Rahmanian ...
来源:[J].International Journal of Cancer(IF 6.198), 2002, Vol.102 (3), pp.212-219
摘要:Abstract(#br)Advanced colorectal cancers are often associated with elevated amounts of hyaluronan. To investigate the importance of hyaluronan in colon carcinoma tumor progression, we have expressed by stable transfection hyaluronan synthase 2 (Has2) and hyaluronidase 1 (Hya...
作者:... Göran Andersson , Annica Jacobson , Håkan Melhus
来源:[J].PLOS ONE(IF 3.73), 2013, Vol.8 (12)
摘要:An excessive intake of vitamin A has been associated with an increased risk of fractures in humans. In animals, a high vitamin A intake leads to a reduction of long bone diameter and spontaneous fractures. Studies in rodents indicate that the bone thinning is due to increased per...
作者:... Anders Sundqvist , Annica Jacobson , Håkan Melhus
来源:[J].PLOS ONE(IF 3.73), 2010, Vol.5 (10)
摘要:It has been shown that high vitamin A intake is associated with bone fragility and fractures in both animals and humans. However, the mechanism by which vitamin A affects bones is unclear. In the present study, the direct effects of retinoic acid (RA) on human and murine ost...

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